{"id":"W4283385779","doi":"10.1093/brain/awac223","title":"Endocannabinoid dysfunction in neurological disease: neuro-ocular DAGLA-related syndrome","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Common Fund; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Biogen; National Human Genome Research Institute; National Institutes of Health; Canadian Institutes of Health Research; bluebird bio","keywords":"Haploinsufficiency; Biology; Phenotype; Endocannabinoid system; Ataxia; Exon; Genetics; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005808509,0.0001837419,0.0002985884,0.0003472268,0.0001964263,0.00002683766,0.0001908449,0.00006228001,0.003559747],"category_scores_gemma":[0.0006075323,0.0001727425,0.0001753882,0.0008884947,0.0001023497,0.00006784575,0.0002841255,0.0009219447,0.00005899901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197664,"about_ca_system_score_gemma":0.0002597622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000687541,"about_ca_topic_score_gemma":0.000006329832,"domain_scores_codex":[0.9973837,0.0003984067,0.0003407028,0.0005625287,0.0007771225,0.0005375419],"domain_scores_gemma":[0.9990464,0.00003499582,0.00005410332,0.0004569921,0.00004195865,0.0003655155],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.003459425,0.002412147,0.2051174,0.0002595212,0.00009877093,0.04662644,0.0003377536,0.002816111,0.01666936,0.004235919,0.7019026,0.01606458],"study_design_scores_gemma":[0.002423836,0.001044351,0.6719013,0.000009031672,0.00002373971,0.001019846,0.0000576418,0.002789772,0.00002346042,0.0003666545,0.3201729,0.0001674521],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8927041,0.0005351346,0.000009893741,0.1045439,0.0003182378,0.0007280802,0.0000289931,0.0001146664,0.001016933],"genre_scores_gemma":[0.9678496,0.00001334389,0.000007110671,0.006092706,0.00005455987,0.0004045052,0.0001246027,0.00004217166,0.02541148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4667839,"threshold_uncertainty_score":0.9973511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080102209972955,"score_gpt":0.256008818953079,"score_spread":0.2452077968533495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}