{"id":"W4283385779","doi":"10.1093/brain/awac223","title":"Endocannabinoid dysfunction in neurological disease: neuro-ocular DAGLA-related syndrome","year":2022,"lang":"en","type":"article","venue":"Brain","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Common Fund; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; Biogen; National Human Genome Research Institute; National Institutes of Health; Canadian Institutes of Health Research; bluebird bio","keywords":"Haploinsufficiency; Biology; Phenotype; Endocannabinoid system; Ataxia; Exon; Genetics; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257515,0.0008806335,0.0003691092,0.001021462,0.0005967165,0.0002325551,0.000341787,0.0005154499,0.002336128],"category_scores_gemma":[0.0007451398,0.0001652648,0.0002394753,0.0005869105,0.0007949265,0.0001830336,0.0007480836,0.0003737074,0.0002662323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003148525,"about_ca_system_score_gemma":0.0004720503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001818467,"about_ca_topic_score_gemma":0.002850201,"domain_scores_codex":[0.9998016,0.00002217977,0.00003037792,0.0000601035,0.00004819086,0.00003764213],"domain_scores_gemma":[0.999732,0.00007429382,0.00009513622,0.00002092831,0.00002144042,0.00005627863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0008666416,0.0001456085,0.1651203,0.0004027234,0.0001968256,0.4086403,0.001609699,0.0005535871,0.3945072,0.001203904,0.0005757589,0.02617759],"study_design_scores_gemma":[0.00005363894,0.0003194627,0.2647032,0.0000531121,0.0002112499,0.6730257,0.0005021979,0.0005303225,0.05658312,0.0004801178,0.003494253,0.00004362192],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976331,0.0003588597,0.0008916907,0.00006612541,0.000009175942,0.00001512372,0.0002316082,0.00002866135,0.0007656937],"genre_scores_gemma":[0.9982022,0.00029838,0.0009045894,0.00003026454,0.000007045953,0.000007678201,0.0001260111,0.000009338771,0.0004144169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002336128,"threshold_uncertainty_score":0.007815063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080102209972955,"score_gpt":0.256008818953079,"score_spread":0.2452077968533495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}