{"id":"W4283387608","doi":"10.3791/63223","title":"Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics","year":2022,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Association for Co-operative Education; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco; University of Toronto; Canada Research Chairs; Arizona Biomedical Research Commission; International Development Research Centre; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Molecular diagnostics; Computer science; Zika virus; Chikungunya; Loop-mediated isothermal amplification; Risk analysis (engineering); Computational biology; Systems engineering; Medicine; Bioinformatics; Biology; Engineering; Virology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003761833,0.0001072791,0.000297145,0.0001453957,0.0001178338,0.00001581491,0.00006195015,0.00001367584,0.0001560046],"category_scores_gemma":[0.00007269538,0.00009473713,0.00006859776,0.0001039106,0.000005625539,0.00005799941,0.00004180951,0.00004960551,2.958132e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001492142,"about_ca_system_score_gemma":0.0001998744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009437617,"about_ca_topic_score_gemma":3.930262e-7,"domain_scores_codex":[0.9984168,0.0001141576,0.0006629248,0.0001273299,0.0005456188,0.0001331417],"domain_scores_gemma":[0.9990377,0.0001092802,0.0004057006,0.00009682147,0.0002106791,0.0001398499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.03580494,0.02297916,0.04577492,0.0002266792,0.001994352,0.0001542509,0.05771605,0.002405225,0.6292302,0.000122128,0.0103549,0.1932372],"study_design_scores_gemma":[0.02807289,0.02080823,0.01395705,0.00008396867,0.0004906219,0.00001236623,0.02915662,0.0003054764,0.9004752,0.00002166552,0.006390763,0.0002251249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836751,0.0004113254,0.01386185,0.0001465074,0.0001474895,0.001737398,0.00001262353,0.00000451918,0.000003194968],"genre_scores_gemma":[0.9918304,0.000005773354,0.007120053,0.0006143759,0.00003063991,0.0003595083,0.00001670631,0.00001648928,0.000006042628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.271245,"threshold_uncertainty_score":0.3863268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06289588670924791,"score_gpt":0.4549098511143217,"score_spread":0.3920139644050738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}