{"id":"W4283387608","doi":"10.3791/63223","title":"Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics","year":2022,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Association for Co-operative Education; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco; University of Toronto; Canada Research Chairs; Arizona Biomedical Research Commission; International Development Research Centre; National Institute of Allergy and Infectious Diseases; Bill and Melinda Gates Foundation","keywords":"Molecular diagnostics; Computer science; Zika virus; Chikungunya; Loop-mediated isothermal amplification; Risk analysis (engineering); Computational biology; Systems engineering; Medicine; Bioinformatics; Biology; Engineering; Virology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02028028,0.001091834,0.0005493482,0.0008247996,0.0007693989,0.001972684,0.002175426,0.001706474,0.02180726],"category_scores_gemma":[0.01948415,0.0004404826,0.001192151,0.0004582092,0.0007171275,0.001264075,0.001791892,0.001204145,0.005032538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002891094,"about_ca_system_score_gemma":0.009223753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003783387,"about_ca_topic_score_gemma":0.002328384,"domain_scores_codex":[0.9875222,0.007188573,0.0007142243,0.001199717,0.002204101,0.001171153],"domain_scores_gemma":[0.988863,0.002931107,0.0007019112,0.001530764,0.004840193,0.001133058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009431661,0.009323965,0.0352553,0.002881386,0.0003274813,0.001026044,0.001625912,0.01669669,0.05137764,0.02721108,0.03157341,0.8132694],"study_design_scores_gemma":[0.01421385,0.1210279,0.07166179,0.002445642,0.001260085,0.002325832,0.00486782,0.1102781,0.1711011,0.01921465,0.4811591,0.0004442727],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1607726,0.0007345641,0.7030318,0.004445821,0.001156222,0.07812235,0.004164968,0.004766487,0.04280515],"genre_scores_gemma":[0.3915938,0.0005794026,0.5300068,0.002865543,0.0001287706,0.05129117,0.002795401,0.0003995196,0.02033959],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02180726,"threshold_uncertainty_score":0.1072537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06289588670924791,"score_gpt":0.4549098511143217,"score_spread":0.3920139644050738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}