{"id":"W4283389428","doi":"10.1016/j.molcel.2022.06.004","title":"Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; York University; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Mitophagy; Biology; Cell biology; Mitochondrion; Lipid-anchored protein; Endoplasmic reticulum; Autophagy; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002592932,0.0004808091,0.0005744047,0.0002652847,0.0006554571,0.0007984107,0.0003487337,0.0004775175,0.002990879],"category_scores_gemma":[0.0002271599,0.0002850537,0.0005756069,0.0002140834,0.0004453723,0.0008210963,0.0006888181,0.001071555,0.001311372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008465755,"about_ca_system_score_gemma":0.0003832494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009424246,"about_ca_topic_score_gemma":0.001108548,"domain_scores_codex":[0.9997057,0.0000407886,0.00002963907,0.00007610198,0.00005003218,0.00009765883],"domain_scores_gemma":[0.9997815,0.00001612708,0.00007579281,0.00002495074,0.00004349838,0.00005805836],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000812535,0.00003570751,0.0006287085,0.00008605416,0.00001279646,0.0001255559,0.00004875884,0.00006464549,0.9956722,0.0003858519,0.0004551653,0.001671917],"study_design_scores_gemma":[0.000106417,0.000226765,0.05180342,0.00003624342,0.00005583112,0.0005969267,0.0003893271,0.002468691,0.9363313,0.000535293,0.007413366,0.00003652496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815409,0.006177039,0.005482434,0.001261583,0.0002245861,0.00003423587,0.001051425,0.000429671,0.003798062],"genre_scores_gemma":[0.9891697,0.001435717,0.001950964,0.0002242685,0.00004564568,0.00004482086,0.001028862,0.0001043083,0.005995801],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002990879,"threshold_uncertainty_score":0.01000547,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0057665647058536,"score_gpt":0.2281078009843254,"score_spread":0.2223412362784718,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}