{"id":"W4283390621","doi":"10.1200/jco.21.02741","title":"Biochemical Failure Is Not a Surrogate End Point for Overall Survival in Recurrent Prostate Cancer: Analysis of NRG Oncology/RTOG 9601","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Hamilton Health Sciences","funders":"National Cancer Institute","keywords":"Medicine; Prostate cancer; Prostatectomy; Oncology; Prostate-specific antigen; Internal medicine; Surrogate endpoint; Hazard ratio; Urology; Radiation therapy; Clinical endpoint; Biochemical recurrence; Prostate; Salvage therapy; Stage (stratigraphy); Cancer; Clinical trial; Chemotherapy; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02627014,0.0007484679,0.002621786,0.0008033721,0.0001881383,0.001113818,0.0007720403,0.0006415154,0.001031124],"category_scores_gemma":[0.02250219,0.0003914039,0.00841069,0.001026385,0.0006398406,0.0004447077,0.0006027087,0.0009693898,0.0001530662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007038389,"about_ca_system_score_gemma":0.0009966053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001415782,"about_ca_topic_score_gemma":0.002502755,"domain_scores_codex":[0.9848282,0.01192472,0.0009083842,0.0009508148,0.001107608,0.0002804171],"domain_scores_gemma":[0.980724,0.0104845,0.005469164,0.002355246,0.0005106631,0.0004564727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3180227,0.0004261463,0.3552943,0.006539317,0.2049804,0.0003673632,0.000299635,0.007274652,0.005328676,0.000952358,0.002127805,0.09838683],"study_design_scores_gemma":[0.05428232,0.04614753,0.5858517,0.0009135795,0.283857,0.0009595896,0.0002121341,0.01140548,0.004046279,0.003708654,0.008448162,0.0001676718],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486253,0.0448642,0.002565318,0.0005417258,0.00009619928,0.0004648079,0.001455139,0.00005488818,0.001332411],"genre_scores_gemma":[0.9967144,0.00159142,0.0005431771,0.0002045831,0.00004293057,0.0001885472,0.000432626,0.00001107748,0.000271237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02627014,"threshold_uncertainty_score":0.1389314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1086920417945377,"score_gpt":0.4688955939346918,"score_spread":0.3602035521401541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}