{"id":"W4283393651","doi":"10.1002/eji.202249888","title":"PTEN is required for human Treg suppression of costimulation in vitro","year":2022,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; BC Children's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"PTEN; Biology; PI3K/AKT/mTOR pathway; FOXP3; Cancer research; Immunology; Protein kinase B; Phenotype; Cell biology; Signal transduction; Immune system; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001188243,0.0001871897,0.0005724625,0.0004980532,0.0002772015,0.000005569419,0.0006232234,0.0001000978,0.0008799933],"category_scores_gemma":[0.0001094693,0.0001726849,0.0002368141,0.0001879246,0.0002714754,0.0001020065,0.000283095,0.0006836351,0.00003678411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008822737,"about_ca_system_score_gemma":0.00006730168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001604722,"about_ca_topic_score_gemma":0.000001071796,"domain_scores_codex":[0.996558,0.001674298,0.001117219,0.0002219647,0.00005636884,0.000372134],"domain_scores_gemma":[0.9982601,0.0002298028,0.001029941,0.000302482,0.0001624846,0.00001519002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00320883,0.0003746717,0.0002048849,0.00001091142,0.0002397551,0.00004957942,0.001222063,0.00009970333,0.9779139,0.0001312212,0.002954267,0.01359021],"study_design_scores_gemma":[0.01157975,0.003532718,0.003914208,0.00004648931,0.00008635144,0.0007246243,0.0009890798,0.0000268887,0.8758914,0.0004313168,0.1025301,0.000247052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897314,0.005934766,0.0004733166,0.00063338,0.001767297,0.0002521031,0.00007153334,0.0000188186,0.001117393],"genre_scores_gemma":[0.997763,0.00007187714,0.0002865784,0.0001456212,0.00004210408,0.000006547416,0.0001121464,0.0000356012,0.001536558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1020225,"threshold_uncertainty_score":0.9635309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02241186334928234,"score_gpt":0.2520755437569472,"score_spread":0.2296636804076649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}