{"id":"W4283393824","doi":"10.1016/j.psychres.2022.114689","title":"Epigenetic age dysregulation in individuals with bipolar disorder and schizophrenia","year":2022,"lang":"en","type":"article","venue":"Psychiatry Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Island Health; Ontario Shores Centre for Mental Health Sciences; Humber River Regional Hospital; Centre for Addiction and Mental Health; St. Michael's Hospital; McGill University Health Centre","funders":"Department of Psychiatry, University of Toronto; University of Toronto; American Foundation for Suicide Prevention","keywords":"Epigenetics; Bipolar disorder; Schizophrenia (object-oriented programming); Disease; Medicine; Biology; Bioinformatics; Oncology; Psychiatry; Internal medicine; Mood; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001772496,0.0001611652,0.0001870515,0.0003909615,0.0002429744,0.0002256718,0.0000681224,0.0001501483,0.000859183],"category_scores_gemma":[0.0004382511,0.0001102671,0.0001167737,0.0003115192,0.0001243536,0.0001068938,0.0002315201,0.0001279827,0.00008301897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002006036,"about_ca_system_score_gemma":0.0001253519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004811499,"about_ca_topic_score_gemma":0.01267257,"domain_scores_codex":[0.9999268,0.00001424404,0.000006533306,0.00002460798,0.00001395654,0.00001383937],"domain_scores_gemma":[0.999885,0.00001238749,0.00006117357,0.00000852759,0.00001423741,0.00001883266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008539262,0.00003605128,0.9589971,0.00003824213,0.0001035759,0.0001632239,0.0006547261,0.00009635789,0.0273148,0.00006439616,0.0001586561,0.01151888],"study_design_scores_gemma":[0.000002728382,0.00005418241,0.9992662,0.000002799068,0.00001274024,0.00008942596,0.0001317406,0.00004595775,0.0002713454,0.00004192322,0.00007926344,0.000001722135],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995136,0.0001378353,0.00006399093,0.00001284113,0.000002165802,0.000002352209,0.0001223869,0.000001993781,0.0001428954],"genre_scores_gemma":[0.999449,0.0001036513,0.0001280027,0.00001884547,0.00000193063,0.000004421123,0.0001307542,0.000001172379,0.000162247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004811499,"threshold_uncertainty_score":0.009566963,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02117010813377275,"score_gpt":0.3169562678609331,"score_spread":0.2957861597271604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}