{"id":"W4283393824","doi":"10.1016/j.psychres.2022.114689","title":"Epigenetic age dysregulation in individuals with bipolar disorder and schizophrenia","year":2022,"lang":"en","type":"article","venue":"Psychiatry Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Island Health; Ontario Shores Centre for Mental Health Sciences; Humber River Regional Hospital; Centre for Addiction and Mental Health; St. Michael's Hospital; McGill University Health Centre","funders":"Department of Psychiatry, University of Toronto; University of Toronto; American Foundation for Suicide Prevention","keywords":"Epigenetics; Bipolar disorder; Schizophrenia (object-oriented programming); Disease; Medicine; Biology; Bioinformatics; Oncology; Psychiatry; Internal medicine; Mood; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001039193,0.0001031606,0.00009659676,0.0002345477,0.0003065068,0.00004147647,0.0001703272,0.00006636664,0.00005113724],"category_scores_gemma":[0.00003143553,0.0001001874,0.00002154676,0.0004469875,0.0001037553,0.000003672927,0.0002497517,0.0002827522,0.00000286631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001775456,"about_ca_system_score_gemma":0.0001337181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001026505,"about_ca_topic_score_gemma":0.0007180645,"domain_scores_codex":[0.9983284,0.0003778464,0.0001693294,0.0003909172,0.0004239991,0.0003095134],"domain_scores_gemma":[0.9995183,0.00002196014,0.00003898898,0.0002995602,0.00004799356,0.00007316109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001229326,0.0001272572,0.9653722,0.00001677981,0.00002390267,0.000001803887,0.0000843136,0.000755979,0.02547886,0.0003542596,0.0001023718,0.007559324],"study_design_scores_gemma":[0.001495688,0.001043426,0.9398777,0.000009403086,0.000007944474,0.000005076622,0.0003143369,0.0001849523,0.001533718,0.003314435,0.05198592,0.0002273353],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797591,0.01878889,0.0001982744,0.0005549945,0.0000840983,0.0003252254,0.00001814906,0.000005663486,0.0002655872],"genre_scores_gemma":[0.9969119,0.0004136693,0.001973296,0.00002593182,0.0001087686,0.0001154572,0.0001369205,0.00002647277,0.0002875535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05188355,"threshold_uncertainty_score":0.4085525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02117010813377275,"score_gpt":0.3169562678609331,"score_spread":0.2957861597271604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}