{"id":"W4283395265","doi":"10.3390/metabo12070588","title":"Post-Transcriptional Effects of miRNAs on PCSK7 Expression and Function: miR-125a-5p, miR-143-3p, and miR-409-3p as Negative Regulators","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"microRNA; Function (biology); Biology; miR-155; Cell biology; Computational biology; Cancer research; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003502559,0.0005149485,0.0004751522,0.0003465636,0.0002739929,0.0006578514,0.0002221953,0.0003055834,0.0007169135],"category_scores_gemma":[0.0004438262,0.0002976317,0.0005554776,0.0002215931,0.000433918,0.0003021133,0.0003502012,0.000607987,0.0004293279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005249145,"about_ca_system_score_gemma":0.0004428356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006749234,"about_ca_topic_score_gemma":0.0006159986,"domain_scores_codex":[0.9995502,0.000058881,0.00003863632,0.0001294442,0.0001603766,0.0000625531],"domain_scores_gemma":[0.9998172,0.00004351957,0.00005039872,0.00001465197,0.00004906877,0.00002510338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002577635,0.0000191945,0.001103619,0.0001022063,0.00001907208,0.0001201537,0.00005624675,0.0002403273,0.9924798,0.0003959808,0.00006526804,0.005140414],"study_design_scores_gemma":[0.00001931673,0.0001256115,0.00895438,0.00001074798,0.00005448168,0.0003456812,0.00003771098,0.003790117,0.9833282,0.0002363083,0.003084602,0.00001277901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646762,0.01159979,0.01809015,0.0001950346,0.0000967774,0.00008740816,0.0006160761,0.0003384848,0.004299995],"genre_scores_gemma":[0.986406,0.002073295,0.008425526,0.00009843365,0.00002177494,0.00008449762,0.0006273066,0.00005165477,0.002211455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007169135,"threshold_uncertainty_score":0.003808498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004784767097626936,"score_gpt":0.2176762356706012,"score_spread":0.2128914685729743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}