{"id":"W4283395265","doi":"10.3390/metabo12070588","title":"Post-Transcriptional Effects of miRNAs on PCSK7 Expression and Function: miR-125a-5p, miR-143-3p, and miR-409-3p as Negative Regulators","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"microRNA; Function (biology); Biology; miR-155; Cell biology; Computational biology; Cancer research; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001491608,0.0002414752,0.000260443,0.0001143951,0.0002240449,0.00002703521,0.0001151736,0.0001132584,0.0001555967],"category_scores_gemma":[0.0001339945,0.0002313339,0.0001158302,0.0001333672,0.0001589758,0.00001680513,0.0001445602,0.0001228473,0.00000330344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001826483,"about_ca_system_score_gemma":0.00005973916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000320131,"about_ca_topic_score_gemma":0.000004356625,"domain_scores_codex":[0.9984388,0.0002571151,0.0002679266,0.0005071783,0.0003109751,0.0002179477],"domain_scores_gemma":[0.9992051,0.00007194268,0.0001617132,0.0003104242,0.0001204108,0.0001303832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006446645,0.0001417526,0.001619656,0.0001143356,0.0001069546,0.000002847246,0.0001909507,0.00002511582,0.9945823,0.0007237335,0.0009107466,0.0009369501],"study_design_scores_gemma":[0.001265576,0.0005150798,0.1177844,0.00003839154,0.000111893,0.00001935231,0.00014947,0.00001837062,0.8382811,0.0007301677,0.04085524,0.0002310002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807611,0.017936,0.00005991826,0.0002008275,0.0002888743,0.0004218419,0.0001480522,0.00001773329,0.0001657251],"genre_scores_gemma":[0.9978061,0.0001810213,0.00048958,0.0002963589,0.0001496494,0.00009809298,0.0003158958,0.00003195799,0.000631305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1563012,"threshold_uncertainty_score":0.9433523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004784767097626936,"score_gpt":0.2176762356706012,"score_spread":0.2128914685729743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}