{"id":"W4283397106","doi":"10.2337/db22-0138","title":"Insulin Response to Oral Glucose and Cardiometabolic Disease: A Mendelian Randomization Study to Assess Potential Causality","year":2022,"lang":"en","type":"article","venue":"Diabetes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Public Health Ontario; University of Toronto; University Health Network","funders":"National Cancer Institute; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Mental Health; Diabetes Canada","keywords":"Mendelian randomization; Internal medicine; Medicine; Endocrinology; Type 2 diabetes; Hyperinsulinemia; Insulin; Coronary artery disease; Body mass index; Postprandial; Triglyceride; Diabetes mellitus; Odds ratio; Cholesterol; Insulin resistance; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02279149,0.001674203,0.00192308,0.001056126,0.0007593268,0.0009090477,0.001229326,0.001797635,0.002655031],"category_scores_gemma":[0.0327264,0.0007818685,0.002567436,0.001299726,0.001532127,0.0005899367,0.0006875969,0.001102519,0.0002795783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005936929,"about_ca_system_score_gemma":0.0008386308,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001894112,"about_ca_topic_score_gemma":0.0008342683,"domain_scores_codex":[0.9689459,0.02442881,0.001154274,0.003258003,0.001559895,0.0006531791],"domain_scores_gemma":[0.9797202,0.0124493,0.002568078,0.004282391,0.0005463447,0.0004336349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2028095,0.004453121,0.6719115,0.001242235,0.03034639,0.003526675,0.001518953,0.002936635,0.01528626,0.01302311,0.001968811,0.05097682],"study_design_scores_gemma":[0.07767998,0.1017222,0.5991619,0.0004739138,0.04381519,0.01273,0.0008766582,0.1163524,0.01136715,0.0264924,0.008772785,0.0005553821],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672682,0.001317388,0.02882614,0.0002754718,0.0001718378,0.0009292417,0.00037524,0.0001389246,0.0006976504],"genre_scores_gemma":[0.9834026,0.000217922,0.0144165,0.0002270915,0.00006421631,0.0009129185,0.0001784244,0.00003551973,0.0005448572],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02279149,"threshold_uncertainty_score":0.1205344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589285752789356,"score_gpt":0.2874595305680347,"score_spread":0.2715666730401412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}