{"id":"W4283397661","doi":"10.1097/01.hs9.0000846624.61314.38","title":"P939: SYNERGISTIC EFFECTS OF LOW DOSE BELANTAMAB MAFODOTIN IN COMBINATION WITH A GAMMA-SECRETASE INHIBITOR (NIROGACESTAT) IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM): DREAMM-5 STUDY","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Medicine; Multiple myeloma; Refractory (planetary science); Cohort; Adverse effect; Internal medicine; Pharmacology; Combination therapy; Oncology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00114502,0.0009565259,0.001703592,0.0004747198,0.0003643614,0.0009515565,0.0009800722,0.000736171,0.002500112],"category_scores_gemma":[0.0006276658,0.0004309162,0.001524033,0.0004449441,0.0006566425,0.000698675,0.0005021761,0.002536292,0.0007231626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001128489,"about_ca_system_score_gemma":0.001072065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009964103,"about_ca_topic_score_gemma":0.002557868,"domain_scores_codex":[0.9994377,0.0002550085,0.00003538463,0.0001035712,0.00008168225,0.00008656533],"domain_scores_gemma":[0.9996106,0.00006791185,0.00007807554,0.00005467721,0.00002024034,0.0001684824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6258685,0.09136152,0.009434631,0.0008339287,0.0027729,0.0004649154,0.0004411474,0.003860131,0.09507073,0.0003835432,0.002947399,0.1665607],"study_design_scores_gemma":[0.2091492,0.7462142,0.02189685,0.00004181337,0.001300102,0.0006772917,0.0001097112,0.001865672,0.01387752,0.0001675881,0.004648727,0.00005128365],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965634,0.001399885,0.0002289088,0.0001611767,0.00004420865,0.0004003515,0.000274578,0.00004471074,0.0008827659],"genre_scores_gemma":[0.9965463,0.0007455932,0.0006818573,0.0002019512,0.00005521188,0.0002725587,0.0005582325,0.00001295711,0.0009251537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002500112,"threshold_uncertainty_score":0.008363724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006609456375418366,"score_gpt":0.2326909364680984,"score_spread":0.22608148009268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}