{"id":"W4283397932","doi":"10.1097/01.hs9.0000844608.72364.51","title":"P430: MOLECULAR CHARACTERIZATION OF CLINICAL RESPONSE IN NEWLY-DIAGNOSED ACUTE MYELOID LEUKEMIA PATIENTS TREATED WITH IVOSIDENIB + AZACITIDINE COMPARED TO PLACEBO + AZACITIDINE","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"IDH1; Isocitrate dehydrogenase; Myeloid leukemia; Medicine; Peripheral blood mononuclear cell; Internal medicine; Bone marrow; Azacitidine; Placebo; Oncology; Gastroenterology; Mutation; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005541502,0.0002158395,0.0007004958,0.0002534776,0.0001386427,0.0003906584,0.0001842873,0.0003777757,0.001699981],"category_scores_gemma":[0.0007716468,0.0001199555,0.0003916453,0.000263351,0.0001798797,0.0002153309,0.0001860667,0.0004428023,0.0002872731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003151078,"about_ca_system_score_gemma":0.0001962998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002765776,"about_ca_topic_score_gemma":0.0004114055,"domain_scores_codex":[0.9997442,0.00008270175,0.00001878331,0.00006517331,0.00005864421,0.00003043797],"domain_scores_gemma":[0.999669,0.00006867517,0.0001224962,0.00001324597,0.00002660702,0.00010007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2427108,0.002951348,0.50485,0.0005560106,0.001574071,0.0004481166,0.0003182301,0.001664152,0.1199437,0.0001435828,0.001540155,0.1232998],"study_design_scores_gemma":[0.003944712,0.04518747,0.9383501,0.00003646389,0.0005608588,0.0008689909,0.00009079114,0.0015262,0.00669717,0.0001266398,0.002587531,0.00002298793],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979149,0.001197033,0.00007620489,0.00004428591,0.00001316727,0.00004694394,0.0001804094,0.000009201207,0.0005178044],"genre_scores_gemma":[0.9987302,0.0002361379,0.0001163911,0.00006183657,0.00002109358,0.00005849708,0.0004312437,0.000003194586,0.0003412807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001699981,"threshold_uncertainty_score":0.005686998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239487869927134,"score_gpt":0.3108922617448699,"score_spread":0.2884973830455986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}