{"id":"W4283397932","doi":"10.1097/01.hs9.0000844608.72364.51","title":"P430: MOLECULAR CHARACTERIZATION OF CLINICAL RESPONSE IN NEWLY-DIAGNOSED ACUTE MYELOID LEUKEMIA PATIENTS TREATED WITH IVOSIDENIB + AZACITIDINE COMPARED TO PLACEBO + AZACITIDINE","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"IDH1; Isocitrate dehydrogenase; Myeloid leukemia; Medicine; Peripheral blood mononuclear cell; Internal medicine; Bone marrow; Azacitidine; Placebo; Oncology; Gastroenterology; Mutation; Biology; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001175866,0.0004215888,0.001235646,0.0003917235,0.0001362698,0.00002481506,0.0003801229,0.0001865961,0.001284571],"category_scores_gemma":[0.0006631379,0.000392061,0.000187309,0.001827045,0.0001539968,0.0001571519,0.00036656,0.0009037023,0.00005926199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001385493,"about_ca_system_score_gemma":0.001318595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002881401,"about_ca_topic_score_gemma":0.00006773794,"domain_scores_codex":[0.9949204,0.0009755255,0.001326576,0.0008416182,0.001235436,0.0007004461],"domain_scores_gemma":[0.9973058,0.0004962551,0.000382343,0.0008660291,0.0004369583,0.000512616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1631188,0.001614872,0.4087856,0.0002069762,0.0005318896,0.004172557,0.0009726062,0.0008500169,0.4133863,0.00003773504,0.003384335,0.002938332],"study_design_scores_gemma":[0.05735031,0.009082534,0.8250989,0.0005033987,0.0003205063,0.0001414915,0.0008131749,0.003405607,0.09620758,0.000008163193,0.006246935,0.0008213843],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951012,0.00002964315,0.0002225994,0.001103424,0.00008934719,0.002595092,0.0003024978,0.0001153948,0.0004407979],"genre_scores_gemma":[0.9943705,0.00003351274,0.001277071,0.0009434952,0.00007569912,0.0005223607,0.001291362,0.0001264293,0.001359525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4163133,"threshold_uncertainty_score":0.9998531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239487869927134,"score_gpt":0.3108922617448699,"score_spread":0.2884973830455986,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}