{"id":"W4283398606","doi":"10.1089/cell.2021.0172","title":"Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming","year":2022,"lang":"en","type":"review","venue":"Cellular Reprogramming","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Reprogramming; Induced pluripotent stem cell; Biology; Amyotrophic lateral sclerosis; Context (archaeology); Neuroscience; Disease; Neural stem cell; Somatic cell; Neurodegeneration; Stem cell; Cell biology; Pathology; Genetics; Embryonic stem cell; Medicine; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004033095,0.0007999022,0.0009565723,0.002070033,0.0001948822,0.0008104672,0.0007039288,0.0008012463,0.002084728],"category_scores_gemma":[0.0002826098,0.0002142919,0.0004287613,0.001191945,0.0003157865,0.0008367749,0.0005911703,0.001118464,0.001604962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003913681,"about_ca_system_score_gemma":0.0005746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005652891,"about_ca_topic_score_gemma":0.0008508847,"domain_scores_codex":[0.9998915,0.00001510555,0.00001507751,0.00002278102,0.0000432682,0.00001233168],"domain_scores_gemma":[0.9998928,0.00004887371,0.00001417425,0.000005671912,0.00002793598,0.00001047818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004514568,0.00006768683,0.0001348669,0.01241113,0.00006888216,0.0003295541,0.00005669335,0.0006575679,0.01061948,0.008055522,0.01322717,0.9543263],"study_design_scores_gemma":[0.00001097571,0.00007821654,0.0004533551,0.002247909,0.000108144,0.001629283,0.00003943904,0.000158793,0.004043748,0.002763672,0.9884444,0.00002204067],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003417413,0.9954321,0.0009068387,0.0001963603,0.0001804416,0.00001458799,0.00004130358,0.00002209295,0.002864443],"genre_scores_gemma":[0.001149665,0.9971308,0.0005846149,0.0001238794,0.00005575012,0.00001475409,0.00005723533,0.000003667061,0.0008796475],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002084728,"threshold_uncertainty_score":0.006974101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07793460556760037,"score_gpt":0.3367254234433227,"score_spread":0.2587908178757223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}