{"id":"W4283446048","doi":"10.1002/ijc.34180","title":"Association of germline <scp>TYK2</scp> variation with lung cancer and <scp>non‐Hodgkin</scp> lymphoma risk","year":2022,"lang":"en","type":"review","venue":"International Journal of Cancer","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Medical Research Council; National Institute for Health and Care Research; Medical Research Council Canada; National Cancer Institute; Cancer Research UK; Center for Strategic Scientific Initiatives, National Cancer Institute; World Health Organization","keywords":"Medicine; Lung cancer; Oncology; Internal medicine; Lymphoma; Cancer; Genome-wide association study; Immunology; Genotype; Biology; Single-nucleotide polymorphism; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007746369,0.0003876661,0.001425349,0.0007278125,0.0001012875,0.00008927816,0.0003299773,0.0002322441,0.0004556531],"category_scores_gemma":[0.001168189,0.0003012524,0.0005849051,0.0003629253,0.00004384704,0.0003126763,0.00009322932,0.0008382378,0.00000256209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002558808,"about_ca_system_score_gemma":0.001979565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006881079,"about_ca_topic_score_gemma":0.0001406834,"domain_scores_codex":[0.9963206,0.0001576942,0.001398229,0.0003191658,0.001544177,0.0002601072],"domain_scores_gemma":[0.9914978,0.001426053,0.005177442,0.0001829074,0.001550179,0.0001656006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001572505,0.0007503151,0.01642239,0.004083717,0.02395564,0.0002375088,0.001917231,0.0009262969,0.0004081743,0.0001303037,0.04006305,0.9109482],"study_design_scores_gemma":[0.002286086,0.0003315881,0.004577341,0.009260016,0.005964488,0.0004435109,0.00008583579,0.0003805354,0.0001373615,0.0000317317,0.9764254,0.00007607729],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01188985,0.9812542,0.0007727916,0.0002484584,0.00333936,0.0005115794,0.0009784409,0.00001968195,0.00098559],"genre_scores_gemma":[0.00268068,0.9917446,0.0002962615,0.0001589171,0.002595677,0.0001109201,0.0001136533,0.00008060815,0.002218721],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9363624,"threshold_uncertainty_score":0.999944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974670133772108,"score_gpt":0.3475090894764274,"score_spread":0.3277623881387064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}