{"id":"W4283453521","doi":"10.3390/cancers14122887","title":"The Extracellular Matrix Stiffening: A Trigger of Prostate Cancer Progression and Castration Resistance?","year":2022,"lang":"en","type":"review","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Université Laval; Hôtel-Dieu de Québec","funders":"Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Prostate Cancer Foundation","keywords":"Prostate cancer; Medicine; Cancer; Prostate; Disease; Stiffening; Oncology; Internal medicine; Extracellular matrix; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004107199,0.0003159779,0.0009723406,0.0001347833,0.0003394022,0.00004268404,0.0001442214,0.0001342498,0.0001931452],"category_scores_gemma":[0.00004865499,0.0001787149,0.0002297345,0.0004557332,0.0003108575,0.0000535941,0.00007620121,0.0005253905,0.000001624575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002148143,"about_ca_system_score_gemma":0.004441177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007941893,"about_ca_topic_score_gemma":0.00005853646,"domain_scores_codex":[0.9979355,0.0001579378,0.0005304713,0.0004371978,0.0005575493,0.0003812966],"domain_scores_gemma":[0.9987344,0.000200304,0.0004629707,0.000367198,0.00008943619,0.0001457585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005378902,0.00001507486,0.00002906659,0.01664619,0.0003268624,0.00009126309,0.0002758963,0.000001786344,0.00001399928,0.00007709478,0.002544475,0.9794404],"study_design_scores_gemma":[0.0008828121,0.0002018865,0.000005974249,0.00853757,0.0008380323,0.00002347533,0.0001364085,0.00001057541,0.00002849708,0.00001985407,0.9891511,0.0001637969],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000201124,0.9959036,9.181569e-7,0.0002218914,0.0002830621,0.002814148,0.0001466108,0.00002668577,0.0004020229],"genre_scores_gemma":[0.00005747511,0.965881,0.00004989675,0.000003504384,0.0001308637,0.002037478,0.0001562354,0.00005906426,0.03162451],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9866067,"threshold_uncertainty_score":0.7878458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06857487869890601,"score_gpt":0.4143794855158802,"score_spread":0.3458046068169742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}