{"id":"W4283456905","doi":"10.1016/j.jbc.2022.102193","title":"Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages","year":2022,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec; Université du Québec à Montréal; Université du Québec à Trois-Rivières; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Cell biology; Wnt signaling pathway; Macrophage polarization; Mitochondrion; Lipid metabolism; Macrophage; Biology; Leishmania donovani; Inflammation; Oxidative phosphorylation; Chemistry; Biochemistry; Signal transduction; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161855,0.0002236112,0.0001799067,0.0002175359,0.0001339161,0.0002586431,0.00008947672,0.0002398028,0.001153513],"category_scores_gemma":[0.0001190859,0.0001065541,0.0001860611,0.0001354918,0.0002053129,0.0001622782,0.0001934519,0.0003009915,0.0002977571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002500236,"about_ca_system_score_gemma":0.0002182766,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005603731,"about_ca_topic_score_gemma":0.00101109,"domain_scores_codex":[0.9998689,0.00003259456,0.0000117873,0.00001406843,0.00002536545,0.00004722217],"domain_scores_gemma":[0.9999328,0.000007666993,0.00002507847,0.000005856714,0.00001123549,0.00001741733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002425239,0.00001609082,0.0003271444,0.00003326067,0.000003188212,0.00003741834,0.000008745014,0.00002487382,0.9986756,0.00007400252,0.00002661904,0.000530453],"study_design_scores_gemma":[0.0000505367,0.0003062832,0.0115453,0.00001411425,0.00002503331,0.0002063785,0.00009411006,0.0007545844,0.9845999,0.000101346,0.002297979,0.000004437072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955673,0.001807312,0.001109991,0.000118026,0.00001890897,0.00001327867,0.0002457467,0.00002905284,0.001090459],"genre_scores_gemma":[0.9952195,0.001008641,0.0007693438,0.00004668424,0.000006168173,0.00003281948,0.000365167,0.000008179478,0.002543364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153513,"threshold_uncertainty_score":0.003858864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01146462533621353,"score_gpt":0.2231888501517281,"score_spread":0.2117242248155146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}