{"id":"W4283459037","doi":"10.1186/s12575-022-00170-2","title":"A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma","year":2022,"lang":"en","type":"article","venue":"Biological Procedures Online","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"","keywords":"Melanoma; Signature (topology); Computational biology; RNA; Cancer research; Biology; Bioinformatics; Medicine; Gene; Genetics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412699,0.0001306895,0.0002007611,0.00004343071,0.00007557916,0.000003050054,0.0001391485,0.0001638412,0.00001877456],"category_scores_gemma":[0.0003598896,0.00009785888,0.00008126635,0.00009666149,0.0001179275,0.000001176742,0.00007075004,0.00008790279,6.375867e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006930771,"about_ca_system_score_gemma":0.0001462974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000434176,"about_ca_topic_score_gemma":0.000008347575,"domain_scores_codex":[0.999139,0.00006295079,0.0002437611,0.0003044872,0.0001016234,0.000148174],"domain_scores_gemma":[0.9994768,0.00007741638,0.0001517453,0.000137817,0.0001144562,0.00004177547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002847541,0.0005310843,0.006469296,0.0001011179,0.00005344061,0.000001473163,0.00001355059,0.00010451,0.9879788,0.00007002515,0.0002071458,0.001622085],"study_design_scores_gemma":[0.002350809,0.02352108,0.02639301,0.00004026287,0.00009869314,0.0001592514,0.0001689652,0.0009624127,0.9312058,0.0003338463,0.01444847,0.0003173755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936249,0.002812614,0.0004096231,0.0001897797,0.0000703821,0.0005010254,0.002360328,0.00001542342,0.00001587756],"genre_scores_gemma":[0.9966488,0.00007168229,0.00174404,0.0002918772,0.00008358869,0.00007643647,0.0009894092,0.00001222094,0.00008197826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05677291,"threshold_uncertainty_score":0.3990569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03382879992296209,"score_gpt":0.2669509403470152,"score_spread":0.2331221404240531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}