{"id":"W4283459037","doi":"10.1186/s12575-022-00170-2","title":"A novel 7 RNA-based signature for prediction of prognosis and therapeutic responses of wild-type BRAF cutaneous melanoma","year":2022,"lang":"en","type":"article","venue":"Biological Procedures Online","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"","keywords":"Melanoma; Signature (topology); Computational biology; RNA; Cancer research; Biology; Bioinformatics; Medicine; Gene; Genetics; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007150678,0.0005499395,0.0005407471,0.002074983,0.0002086725,0.0006862689,0.0003041867,0.0005265777,0.001477108],"category_scores_gemma":[0.001827019,0.0001069862,0.0005185026,0.0007807178,0.0002017469,0.0003281535,0.0003192739,0.0003417287,0.0006233702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00037148,"about_ca_system_score_gemma":0.0004860443,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000624484,"about_ca_topic_score_gemma":0.001217204,"domain_scores_codex":[0.9995533,0.00008530897,0.00005853406,0.0001044775,0.0001387227,0.00005976464],"domain_scores_gemma":[0.9987996,0.0003907867,0.0003604948,0.00006692442,0.0002718791,0.0001103982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003221679,0.0005421217,0.582353,0.0006074011,0.0005599367,0.001280247,0.0001497107,0.02345507,0.1567484,0.001138035,0.004246708,0.2256976],"study_design_scores_gemma":[0.0002217533,0.002785814,0.4513152,0.0002319015,0.001235409,0.005786493,0.0002844274,0.4158176,0.1045163,0.005778459,0.01185162,0.0001749947],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9395152,0.002538652,0.04555892,0.0004422027,0.0001241137,0.0002244293,0.00658632,0.0007900905,0.00422014],"genre_scores_gemma":[0.9723225,0.000332079,0.02213416,0.0001668647,0.0000731238,0.0001166655,0.004060264,0.00002872831,0.0007656073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002074983,"threshold_uncertainty_score":0.004941463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03382879992296209,"score_gpt":0.2669509403470152,"score_spread":0.2331221404240531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}