{"id":"W4283462949","doi":"10.4049/immunohorizons.2200036","title":"A Hemagglutinin 1 Carrying Plant-Based Virus-like Particle Vaccine Generates an Efficacious Cellular Response by Exploiting IL-1 Signaling in Both Adult and Aged Mice","year":2022,"lang":"en","type":"article","venue":"ImmunoHorizons","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); McGill University; McGill University Health Centre","funders":"","keywords":"Immune system; Hemagglutinin (influenza); Immunology; Vaccination; Immunization; Biology; Virus; Population; Virology; Virus-like particle; Influenza A virus; Influenza vaccine; Immunity; Inflammation; Medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002287007,0.0003873543,0.0002424399,0.0002815966,0.00009767106,0.0001920262,0.0001808501,0.0003340444,0.0008143359],"category_scores_gemma":[0.0000857011,0.0001605103,0.0002703675,0.00006285311,0.0002169094,0.0001864759,0.0001562457,0.0008063944,0.0002673982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001755215,"about_ca_system_score_gemma":0.0001316231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002338168,"about_ca_topic_score_gemma":0.0003824563,"domain_scores_codex":[0.9998497,0.00001807732,0.00001287468,0.00004339026,0.00002719554,0.00004879992],"domain_scores_gemma":[0.99983,0.00001152985,0.00005663371,0.00001605969,0.00001487473,0.00007087475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559947,0.00006142333,0.0002213456,0.00001856853,0.000002402924,0.00001940852,0.00001312591,0.00002670165,0.9987931,0.00003346896,0.00002068867,0.000633813],"study_design_scores_gemma":[0.0001035094,0.007427004,0.03082522,0.00002723574,0.00005809769,0.0006646228,0.0001027883,0.00151274,0.9558981,0.0001170137,0.003251426,0.00001231294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964272,0.0006544678,0.001743436,0.00005181715,0.00003082795,0.00005004714,0.0003818289,0.00007253434,0.0005877992],"genre_scores_gemma":[0.9949715,0.0004351903,0.001696963,0.0001049424,0.00002277945,0.00007641685,0.000442977,0.00001820381,0.002230896],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008143359,"threshold_uncertainty_score":0.00272429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008925565867706736,"score_gpt":0.2256922598452205,"score_spread":0.2167666939775138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}