{"id":"W4283463319","doi":"10.3390/cells11121864","title":"Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection","year":2022,"lang":"en","type":"article","venue":"Cells","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute","keywords":"COPD; Parenchyma; Lung; Immune system; Medicine; Immunology; Transcriptome; Pathology; Gene expression profiling; Biology; Gene expression; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008678725,0.0001296356,0.0002283222,0.0004373486,0.0001733498,0.0003926185,0.00007735333,0.0002789321,0.0008749636],"category_scores_gemma":[0.0002173804,0.0001069295,0.0001594442,0.0002681787,0.0001850429,0.0001500947,0.0002246088,0.0002003012,0.0002435146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009366137,"about_ca_system_score_gemma":0.00008123422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005325475,"about_ca_topic_score_gemma":0.0006663031,"domain_scores_codex":[0.9998918,0.00001766294,0.000009705382,0.00003151151,0.00002058935,0.00002874288],"domain_scores_gemma":[0.9999071,0.00001339904,0.00003179248,0.000006490699,0.00001892593,0.00002215797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001844161,0.00007925212,0.35082,0.0000980987,0.00008101757,0.00131513,0.0003939741,0.0001950591,0.6362674,0.0000910462,0.0002053776,0.008609508],"study_design_scores_gemma":[0.000008508275,0.000293657,0.9805868,0.000009072407,0.00004027567,0.001629967,0.0006449847,0.0006593849,0.0155817,0.00008471286,0.0004547485,0.000006232271],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991358,0.0002218032,0.0001729064,0.00002140681,0.000002527399,0.000004844679,0.0001810005,0.000005830922,0.0002539315],"genre_scores_gemma":[0.9991979,0.0001046483,0.0001731072,0.00004032045,0.000005444086,0.000006812633,0.0002551901,0.000002231752,0.0002142298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008749636,"threshold_uncertainty_score":0.002927065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02177723683945429,"score_gpt":0.3485934678192558,"score_spread":0.3268162309798015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}