{"id":"W4283463598","doi":"10.2174/1381612828666220623102537","title":"Associations of Two Common Polymorphisms in <i>MTHFR</i> Gene with Blood Lipidsand Therapeutic Efficacy of Simvastatin","year":2022,"lang":"en","type":"article","venue":"Current Pharmaceutical Design","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Institute of Physical Science and Information Technology, Anhui University; National Natural Science Foundation of China","keywords":"Methylenetetrahydrofolate reductase; Simvastatin; Internal medicine; Genotype; Triglyceride; Medicine; Cholesterol; Blood lipids; Reductase; Endocrinology; Lipoprotein; High-density lipoprotein; Gastroenterology; Biology; Genetics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007576231,0.0001572302,0.0004586774,0.0002361959,0.00008003091,0.000007522,0.0001837027,0.00003115478,0.0003938698],"category_scores_gemma":[0.0000581948,0.0001302566,0.00009539031,0.0008106671,0.0001583041,0.00004765834,0.00009757371,0.0006313212,0.000005273338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008633973,"about_ca_system_score_gemma":0.0002534748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002750545,"about_ca_topic_score_gemma":0.000002124598,"domain_scores_codex":[0.9976689,0.0004882138,0.0004820793,0.0002492343,0.000742881,0.0003687504],"domain_scores_gemma":[0.9987067,0.0006655509,0.0001352663,0.0002338412,0.00009615214,0.0001624674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003842989,0.01567849,0.1978272,0.0002779986,0.0007853073,0.0001258409,0.00129453,0.001622147,0.6766211,0.001058383,0.0007836989,0.1000823],"study_design_scores_gemma":[0.04959406,0.007269669,0.1665178,0.0003163002,0.001890492,0.0001315291,0.000156523,0.02321255,0.7467483,0.0004412419,0.00302473,0.0006968016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930904,0.003596853,0.001307562,0.0004370528,0.0001272885,0.001048298,0.0001182565,0.00002717723,0.0002471452],"genre_scores_gemma":[0.9990174,0.0001733198,0.0004333663,0.0001309895,0.00004856386,0.00005527763,0.00006863176,0.00002557471,0.00004689073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09938549,"threshold_uncertainty_score":0.531171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1481553615437678,"score_gpt":0.4211474818389764,"score_spread":0.2729921202952085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}