{"id":"W4283463598","doi":"10.2174/1381612828666220623102537","title":"Associations of Two Common Polymorphisms in <i>MTHFR</i> Gene with Blood Lipidsand Therapeutic Efficacy of Simvastatin","year":2022,"lang":"en","type":"article","venue":"Current Pharmaceutical Design","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Institute of Physical Science and Information Technology, Anhui University; National Natural Science Foundation of China","keywords":"Methylenetetrahydrofolate reductase; Simvastatin; Internal medicine; Genotype; Triglyceride; Medicine; Cholesterol; Blood lipids; Reductase; Endocrinology; Lipoprotein; High-density lipoprotein; Gastroenterology; Biology; Genetics; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006489581,0.0004675072,0.0004408928,0.0005061561,0.0002940104,0.0003304654,0.0002915824,0.0005591977,0.001314706],"category_scores_gemma":[0.00168348,0.0002208711,0.0005383752,0.0004934352,0.0003604856,0.0001291914,0.0001851627,0.0005244711,0.0001330166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002794496,"about_ca_system_score_gemma":0.0002980295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0024306,"about_ca_topic_score_gemma":0.001837435,"domain_scores_codex":[0.9995783,0.0001079981,0.00005820209,0.0001110551,0.00007879927,0.00006570853],"domain_scores_gemma":[0.9980766,0.0004363193,0.0009331106,0.0001316207,0.0001391495,0.0002831265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002318876,0.00009256695,0.9900518,0.00001750711,0.0002587824,0.0002578959,0.00007351049,0.00009627773,0.004700057,0.00003710534,0.00005740163,0.002038328],"study_design_scores_gemma":[0.00005827645,0.0003838637,0.9976239,0.000003637484,0.0001800562,0.0004818241,0.0000338271,0.0005297064,0.0005709648,0.00004156779,0.00008725768,0.000005192281],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999656,0.0001186499,0.00006115402,0.000028416,0.000003766791,0.000003320129,0.00004269035,0.000002533198,0.00008354404],"genre_scores_gemma":[0.9998042,0.00002265507,0.00006231663,0.000009512737,0.000007596187,0.000002226255,0.0000430897,7.410897e-7,0.0000477203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0024306,"threshold_uncertainty_score":0.004832923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1481553615437678,"score_gpt":0.4211474818389764,"score_spread":0.2729921202952085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}