{"id":"W4283512735","doi":"10.1016/j.annonc.2022.06.008","title":"Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Genentech; Sirtex Medical; Eli Lilly and Company; Ono Pharmaceutical; Daiichi Sankyo Europe; Servier; Alberta Health Services; Alberta Cancer Foundation; Seagen; Pfizer; Incyte; Canadian Institutes of Health Research; Ipsen; BeiGene; Astellas Pharma; Mylan; Les Laboratories Pierre Fabre; Helsinn; Merck KGaA; Halozyme; Sanofi; GlaxoSmithKline; Bristol-Myers Squibb; AstraZeneca; Amgen; Celgene","keywords":"Ipilimumab; Nivolumab; Medicine; Microsatellite instability; Colorectal cancer; Internal medicine; Oncology; Cancer; Gastroenterology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006672568,0.0003159297,0.001084762,0.0002472942,0.0001357732,0.00001081795,0.0002221592,0.0001161062,0.0007406028],"category_scores_gemma":[0.00005362484,0.000274223,0.0002781591,0.0007561115,0.0002853248,0.00009271206,0.000137625,0.0003679901,0.000007658464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009301303,"about_ca_system_score_gemma":0.001046781,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01411885,"about_ca_topic_score_gemma":0.00411202,"domain_scores_codex":[0.9969522,0.0004394075,0.0009020888,0.0006342583,0.000485207,0.0005868414],"domain_scores_gemma":[0.9984912,0.0001652615,0.000470302,0.0004589695,0.0002811553,0.0001331602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3205017,0.011508,0.5198435,0.0007639971,0.00349157,0.0004913158,0.01928588,0.0004879663,0.03420486,0.00003592973,0.005039389,0.08434594],"study_design_scores_gemma":[0.1348765,0.04240935,0.7422975,0.0007821022,0.0008584425,0.00004955997,0.003955358,0.0004208886,0.03483595,0.0001371011,0.03825561,0.001121666],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993826,0.002386172,0.000001426448,0.0006660736,0.0004061083,0.00172033,0.0006445672,0.00008024584,0.0002691024],"genre_scores_gemma":[0.9970066,0.0006763498,0.0002303706,0.0008379312,0.00002501032,0.000380269,0.0005832209,0.0000507815,0.0002095002],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.222454,"threshold_uncertainty_score":0.999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02848691159622867,"score_gpt":0.3066975440504603,"score_spread":0.2782106324542316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}