{"id":"W4283512735","doi":"10.1016/j.annonc.2022.06.008","title":"Nivolumab plus low-dose ipilimumab in previously treated patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: 4-year follow-up from CheckMate 142","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":253,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Genentech; Sirtex Medical; Eli Lilly and Company; Ono Pharmaceutical; Daiichi Sankyo Europe; Servier; Alberta Health Services; Alberta Cancer Foundation; Seagen; Pfizer; Incyte; Canadian Institutes of Health Research; Ipsen; BeiGene; Astellas Pharma; Mylan; Les Laboratories Pierre Fabre; Helsinn; Merck KGaA; Halozyme; Sanofi; GlaxoSmithKline; Bristol-Myers Squibb; AstraZeneca; Amgen; Celgene","keywords":"Ipilimumab; Nivolumab; Medicine; Microsatellite instability; Colorectal cancer; Internal medicine; Oncology; Cancer; Gastroenterology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000898642,0.0004222705,0.000937041,0.0002551446,0.0003563809,0.0007265731,0.000361589,0.0005832688,0.001136637],"category_scores_gemma":[0.0007514302,0.0002206453,0.001336539,0.0003314375,0.0001700011,0.0004064636,0.000273888,0.00100129,0.0003181305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006388358,"about_ca_system_score_gemma":0.0004812357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002454733,"about_ca_topic_score_gemma":0.003834399,"domain_scores_codex":[0.9997572,0.00006273587,0.0000212682,0.00004585549,0.00004814284,0.00006480909],"domain_scores_gemma":[0.9995195,0.00007165443,0.0001281845,0.00004299518,0.0000387182,0.000199001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.187891,0.01600844,0.4390275,0.001301841,0.007048391,0.003687201,0.000668969,0.004051714,0.03919816,0.0001550413,0.007822987,0.2931389],"study_design_scores_gemma":[0.02616286,0.1415672,0.8120745,0.0001539387,0.003045795,0.002763221,0.0001837705,0.002429988,0.004452465,0.0001107859,0.0069802,0.0000754353],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945961,0.003472285,0.0001307435,0.0001570978,0.00003450776,0.0001022432,0.0005868876,0.00001624098,0.000903947],"genre_scores_gemma":[0.9962846,0.00109751,0.0001234753,0.0003797872,0.00005051678,0.0000488905,0.001381022,0.000004808506,0.0006293076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002454733,"threshold_uncertainty_score":0.004880965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02848691159622867,"score_gpt":0.3066975440504603,"score_spread":0.2782106324542316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}