{"id":"W4283519858","doi":"10.1016/j.immuni.2022.06.003","title":"SARS-CoV-2-specific T cell memory with common TCRαβ motifs is established in unvaccinated children who seroconvert after infection","year":2022,"lang":"en","type":"article","venue":"Immunity","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"H2020 Marie Skłodowska-Curie Actions; National Institute of Allergy and Infectious Diseases; Australian Research Council; National Health and Medical Research Council; Horizon 2020 Framework Programme; Research Grants Council, University Grants Committee; University of Melbourne; Royal Children's Hospital Foundation; American Lebanese Syrian Associated Charities; Pfizer; Clifford Craig Foundation; State Government of Victoria; European Commission; Icahn School of Medicine at Mount Sinai; AstraZeneca","keywords":"Biology; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Virology; Coronavirus disease 2019 (COVID-19); Immunological memory; Immunology; T-cell receptor; Memory T cell; Coronavirus; T cell; Medicine; Immunity; Disease; Internal medicine; Immune system; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007000475,0.0002968193,0.000488264,0.000565759,0.0003063717,0.00007592369,0.0003341781,0.0001308862,0.0002702226],"category_scores_gemma":[0.000029932,0.0002758668,0.0001168995,0.001150188,0.00009463318,0.0002891173,0.0004211021,0.00168785,0.00009149961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005879337,"about_ca_system_score_gemma":0.0002517783,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01634838,"about_ca_topic_score_gemma":0.001184556,"domain_scores_codex":[0.9975192,0.0004909778,0.0003813329,0.0004367039,0.0006356969,0.0005360767],"domain_scores_gemma":[0.9985933,0.00009632455,0.0001056167,0.001008015,0.0001546084,0.0000421274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002829072,0.001259017,0.9017151,0.0001191585,0.00008842577,0.0002021421,0.002416415,0.000007638483,0.08592155,0.000004677991,0.002769244,0.002667568],"study_design_scores_gemma":[0.004542978,0.0006828837,0.6006675,0.00006035759,0.00003523012,0.0001032787,0.0002900661,0.0002259176,0.3760905,0.00003919167,0.01697532,0.0002867859],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931552,0.0004537387,0.00001671809,0.0002259036,0.0001513016,0.001007575,0.00002827216,0.0001372696,0.00482403],"genre_scores_gemma":[0.9878815,0.00001515284,0.00001831137,0.01151954,0.0000529793,0.0002303778,0.000052106,0.00006333504,0.0001667074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3010476,"threshold_uncertainty_score":0.9999694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02147625757280978,"score_gpt":0.2910110241852094,"score_spread":0.2695347666123996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}