{"id":"W4283524726","doi":"10.1002/gepi.22489","title":"A Bayesian hierarchical model for improving measurement of 5mC and 5hmC levels: Toward revealing associations between phenotypes and methylation states","year":2022,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; McMaster University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Bisulfite; Biology; Methylation; Epigenetics; Computational biology; Bisulfite sequencing; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002742139,0.000136419,0.000347432,0.00006917982,0.0002031193,0.000005460596,0.00009289175,0.0001267114,0.00000304869],"category_scores_gemma":[0.001387914,0.0001436355,0.00006606574,0.00005599027,0.00007947254,0.000002862283,0.0001752167,0.0001109702,6.232544e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003585436,"about_ca_system_score_gemma":0.00008560179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006839391,"about_ca_topic_score_gemma":0.00003326091,"domain_scores_codex":[0.9981404,0.0004982637,0.0005573384,0.0004102656,0.0001281527,0.0002655678],"domain_scores_gemma":[0.9989519,0.0003485379,0.0003113062,0.0001732249,0.0001329504,0.0000821455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001251687,0.00006942431,0.1565096,0.0002010921,0.0002810415,2.757508e-7,0.001135117,0.09558755,0.6005952,0.001052398,0.00008807214,0.1443551],"study_design_scores_gemma":[0.001856997,0.001689604,0.2199311,0.00001434908,0.0003506659,0.000003137577,0.0002462793,0.5967192,0.04836599,0.1290186,0.001140186,0.0006638288],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4493259,0.005251596,0.5444736,0.0004496339,0.00003659106,0.0002541094,0.000192359,0.000005032588,0.00001120349],"genre_scores_gemma":[0.9168906,0.0002222918,0.08235942,0.0001124375,0.00009852064,0.00007709994,0.0002016412,0.00001914712,0.00001879104],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5522292,"threshold_uncertainty_score":0.5857285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09871131704176604,"score_gpt":0.3293300413000897,"score_spread":0.2306187242583236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}