{"id":"W4283524726","doi":"10.1002/gepi.22489","title":"A Bayesian hierarchical model for improving measurement of 5mC and 5hmC levels: Toward revealing associations between phenotypes and methylation states","year":2022,"lang":"en","type":"article","venue":"Genetic Epidemiology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; McGill University; McMaster University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"DNA methylation; Bisulfite; Biology; Methylation; Epigenetics; Computational biology; Bisulfite sequencing; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008268915,0.001423715,0.002201066,0.001571506,0.001002946,0.001347514,0.004465644,0.002080543,0.002281454],"category_scores_gemma":[0.01811882,0.001341922,0.002266617,0.001715678,0.001763066,0.001730195,0.002177639,0.003337357,0.0006916852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001751013,"about_ca_system_score_gemma":0.003217322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0340208,"about_ca_topic_score_gemma":0.03977533,"domain_scores_codex":[0.9969476,0.001716455,0.0001073185,0.0006737663,0.0003658539,0.0001891217],"domain_scores_gemma":[0.9909086,0.0069526,0.0006317851,0.0005327775,0.0006888094,0.0002854558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000588348,0.0001926212,0.01212172,0.0003664872,0.0006317372,0.0002579416,0.0005031694,0.7559331,0.007002568,0.08730409,0.004484311,0.1306139],"study_design_scores_gemma":[0.00004583199,0.00004618198,0.001128728,0.00002843527,0.00005922553,0.000031136,0.00001651723,0.9697842,0.0005555487,0.02697647,0.001288986,0.00003875399],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.008717562,0.0002854864,0.9897983,0.0002672595,0.00002640326,0.00006652215,0.0002353077,0.0002418206,0.0003613129],"genre_scores_gemma":[0.2447141,0.0009672183,0.7448029,0.0009194714,0.0002253855,0.0008687251,0.002371865,0.0003100904,0.004820298],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0340208,"threshold_uncertainty_score":0.06764555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09871131704176604,"score_gpt":0.3293300413000897,"score_spread":0.2306187242583236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}