{"id":"W4283528562","doi":"10.19163/medchemrussia2021-2022-11","title":"C,N-CHELATED DIAMINOCARBENE PLATINUM COMPLEXES, A NEW CHEMICAL SPACE FOR THE DEVELOPMENT OF PLATINUM-BASED ANTICANCER DRUGS","year":2022,"lang":"ru","type":"article","venue":"","topic":"Asymmetric Hydrogenation and Catalysis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Platinum; Platinum compounds; Chelation; Space (punctuation); Chemical space; Combinatorial chemistry; Chemistry; Materials science; Computer science; Organic chemistry; Drug discovery; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001979933,0.0002557337,0.0002967369,0.0001776618,0.0002135574,0.0004384291,0.000849854,0.0003365464,0.001837472],"category_scores_gemma":[0.0002948216,0.000127009,0.0000909524,0.0001658212,0.00037688,0.0005426107,0.0005684063,0.0004465645,0.0005028371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004092377,"about_ca_system_score_gemma":0.0002697141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003358568,"about_ca_topic_score_gemma":0.0005270073,"domain_scores_codex":[0.9998311,0.00004032738,0.00001178359,0.00003788219,0.00005567126,0.00002325791],"domain_scores_gemma":[0.9999194,0.00001429257,0.00002197394,0.00001570046,0.000008361951,0.00002031446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007433437,0.00007295792,0.0003151985,0.000455175,0.00002372114,0.0004508743,0.000091993,0.0009075864,0.9346336,0.01830991,0.002682235,0.04131352],"study_design_scores_gemma":[0.00008479839,0.0009378153,0.0007769573,0.00002479704,0.00002907795,0.001540422,0.00004131538,0.001979024,0.9492688,0.001283087,0.04401013,0.00002371821],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.845329,0.02607772,0.04148332,0.001161256,0.0003428437,0.0001148526,0.0005670338,0.0009693814,0.08395462],"genre_scores_gemma":[0.9870551,0.003355596,0.004501757,0.0002690321,0.00005065952,0.0000263438,0.0002219999,0.00003247625,0.004487034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001837472,"threshold_uncertainty_score":0.006146908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01989480270863187,"score_gpt":0.2574284343127518,"score_spread":0.2375336316041199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}