{"id":"W4283528698","doi":"10.3390/ijms23137086","title":"Cathepsin B p.Gly284Val Variant in Parkinson’s Disease Pathogenesis","year":2022,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital","funders":"National Institute on Aging; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Narodowa Agencja Wymiany Akademickiej; American Parkinson Disease Association; Congressionally Directed Medical Research Programs; Center for Individualized Medicine, Mayo Clinic; Mayo Clinic; Fundacja na rzecz Nauki Polskiej; Florida Department of Health; Michael J. Fox Foundation for Parkinson's Research","keywords":"Cathepsin B; Proband; Sanger sequencing; Biology; Pathogenesis; Genetics; Medicine; Gene; Immunology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687684,0.0004232145,0.0002791029,0.0006400861,0.0002652442,0.0003464953,0.0001747622,0.0004526523,0.001382242],"category_scores_gemma":[0.0003789708,0.0001226743,0.0002151138,0.0004141937,0.0002875112,0.0001619397,0.0002829128,0.0002184355,0.0002154349],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002197762,"about_ca_system_score_gemma":0.0001749349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009682812,"about_ca_topic_score_gemma":0.0006825185,"domain_scores_codex":[0.9999138,0.00001883306,0.00001095061,0.0000267121,0.00002034633,0.000009240516],"domain_scores_gemma":[0.99986,0.00003087971,0.00005638277,0.00000749636,0.00001553171,0.00002966271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002930005,0.0001656631,0.7415757,0.000278633,0.0003279143,0.04739257,0.0007779842,0.001102372,0.1727251,0.0007803733,0.0006506697,0.03129309],"study_design_scores_gemma":[0.00009415099,0.0003873669,0.9108813,0.00009051796,0.0002414305,0.06731613,0.0003675766,0.001689766,0.01417538,0.001042105,0.003691179,0.00002308434],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978586,0.001270275,0.0002061515,0.00006762828,0.00000492942,0.000004790642,0.00007464354,0.000007255895,0.0005056391],"genre_scores_gemma":[0.9992447,0.000329977,0.0001560291,0.00001416228,0.000006089092,0.000002125185,0.00007238126,0.000002314646,0.0001723118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382242,"threshold_uncertainty_score":0.004624009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01779818048350269,"score_gpt":0.2879992069236496,"score_spread":0.2702010264401469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}