{"id":"W4283528830","doi":"10.4049/jimmunol.2200056","title":"Improved Durability to SARS-CoV-2 Vaccine Immunity following Coimmunization with Molecular Adjuvant Adenosine Deaminase-1","year":2022,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Pennsylvania Department of Community and Economic Development; Coalition for Epidemic Preparedness Innovations; AstraZeneca; Drexel University; Wistar Institute; Public Health Agency; INOVIO Pharmaceuticals; Sanofi; U.S. Department of Health and Human Services; National Institutes of Health; Public Health Agency of Canada","keywords":"Immunogenicity; Immune system; Memory B cell; Immunology; Biology; Adenosine deaminase; Virology; Adjuvant; In vivo; Immunity; Adenosine; B cell; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002237628,0.0003669621,0.0002838425,0.0002027873,0.00008300337,0.000241328,0.0001581789,0.0002872575,0.0008200641],"category_scores_gemma":[0.0002120003,0.00009802964,0.0001712946,0.00006885349,0.0001849007,0.0002553183,0.0001535445,0.0006992425,0.0002124927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303619,"about_ca_system_score_gemma":0.0001284065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009900156,"about_ca_topic_score_gemma":0.0001568451,"domain_scores_codex":[0.9998397,0.00003079929,0.00001168903,0.00003460167,0.00003187127,0.00005143464],"domain_scores_gemma":[0.9998393,0.00003835925,0.00005031627,0.00002343638,0.00001746714,0.00003105411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002691954,0.000137303,0.0002360944,0.00002911502,0.000005657758,0.00002256834,0.0000195176,0.00008744096,0.9961039,0.00004346794,0.00002498178,0.00302081],"study_design_scores_gemma":[0.00006371107,0.00661216,0.00563553,0.00001010996,0.00004270031,0.0003467206,0.00003111337,0.001007524,0.9843141,0.00006188743,0.001868022,0.000006360031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981486,0.0004131548,0.0008392897,0.00003881695,0.00002702473,0.00001424753,0.00004944671,0.00004133757,0.0004281538],"genre_scores_gemma":[0.9980369,0.0002169472,0.0006267934,0.00003739955,0.00001721775,0.00001507072,0.0001166848,0.000008058384,0.000924959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008200641,"threshold_uncertainty_score":0.002743423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088052037034384,"score_gpt":0.3097201487947069,"score_spread":0.2888396284243631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}