{"id":"W4283579431","doi":"10.3390/nano12132179","title":"Nanoparticle-Enabled Combination Therapy Showed Superior Activity against Multi-Drug Resistant Bacterial Pathogens in Comparison to Free Drugs","year":2022,"lang":"en","type":"article","venue":"Nanomaterials","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canada Research Chairs","keywords":"Salmonella enterica; Microbiology; Efflux; Multiple drug resistance; Staphylococcus aureus; Tetracycline; Antibiotics; Antimicrobial; Antibiotic resistance; Salmonella; Hemolysis; Drug resistance; Biology; Pathogen; Bacteria; Biofilm; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009453538,0.000304017,0.0004987739,0.0001138191,0.0002687082,0.0001354347,0.0005683824,0.0001211866,0.000274714],"category_scores_gemma":[0.0001629044,0.0003168093,0.00009796438,0.0002274177,0.00006435854,0.00001840779,0.0005028044,0.00009057256,0.00001357775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001633473,"about_ca_system_score_gemma":0.0001458905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009145511,"about_ca_topic_score_gemma":0.0001544498,"domain_scores_codex":[0.9971588,0.0007621633,0.0006024223,0.0006666343,0.0002941271,0.0005158346],"domain_scores_gemma":[0.9987628,0.00003112122,0.0002182838,0.0007932376,0.00007588545,0.0001186782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003366927,0.0005770708,0.006442735,0.00001839647,0.00003052891,0.00001370132,0.0005839216,0.00005145622,0.9876296,0.00002092314,0.0007865214,0.0004782342],"study_design_scores_gemma":[0.003635566,0.0004064037,0.04898942,0.00001569198,0.000008179962,0.000002626116,0.0003531469,0.00004879389,0.9382738,0.00001394185,0.007865249,0.0003871688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968331,0.00009090243,0.00002434257,0.0002338162,0.001295155,0.0009856087,0.0004106176,0.00004463133,0.00008176945],"genre_scores_gemma":[0.9980643,0.00004103847,0.000628371,0.0001775708,0.000154041,0.0001814517,0.0002854495,0.00006057681,0.000407154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04935577,"threshold_uncertainty_score":0.9999284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649495872481864,"score_gpt":0.2666374988773318,"score_spread":0.2501425401525131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}