{"id":"W4283579431","doi":"10.3390/nano12132179","title":"Nanoparticle-Enabled Combination Therapy Showed Superior Activity against Multi-Drug Resistant Bacterial Pathogens in Comparison to Free Drugs","year":2022,"lang":"en","type":"article","venue":"Nanomaterials","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University","funders":"Canada Research Chairs","keywords":"Salmonella enterica; Microbiology; Efflux; Multiple drug resistance; Staphylococcus aureus; Tetracycline; Antibiotics; Antimicrobial; Antibiotic resistance; Salmonella; Hemolysis; Drug resistance; Biology; Pathogen; Bacteria; Biofilm; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009575599,0.0003896366,0.0006200047,0.0002539282,0.00009379893,0.0002829139,0.0002235269,0.0003868387,0.0008625979],"category_scores_gemma":[0.0001055949,0.0001331879,0.0003069276,0.0001551866,0.0001520569,0.0002279487,0.0002003005,0.0004355373,0.000254524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236689,"about_ca_system_score_gemma":0.0001521585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004365227,"about_ca_topic_score_gemma":0.001135762,"domain_scores_codex":[0.9998831,0.00001566727,0.000007368888,0.00003528718,0.00003700636,0.00002165566],"domain_scores_gemma":[0.9999478,0.0000106686,0.000011242,0.000006119296,0.00001358005,0.00001062438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004729153,0.0002065303,0.0001551367,0.0002104929,0.00003203687,0.00007958194,0.00001976364,0.0004222695,0.9763305,0.00006894406,0.000226689,0.0217753],"study_design_scores_gemma":[0.0001027505,0.00547765,0.003437271,0.00002029499,0.0001467872,0.0005957585,0.00002272268,0.002994388,0.9754753,0.00005904009,0.01164181,0.00002634874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696047,0.01567706,0.008919524,0.0002124183,0.0002564933,0.0001781115,0.000233755,0.0002240988,0.004693833],"genre_scores_gemma":[0.9865863,0.004086243,0.004488085,0.0001013392,0.00003796352,0.00007238574,0.000216268,0.00002838646,0.004383015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008625979,"threshold_uncertainty_score":0.002885699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01649495872481864,"score_gpt":0.2666374988773318,"score_spread":0.2501425401525131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}