{"id":"W4283582239","doi":"10.1007/s12346-022-00627-5","title":"Dynamic Analysis of a Model on Tumor-Immune System with Regulation of PD-1/PD-L1 and Stimulation Delay of Tumor Antigen","year":2022,"lang":"en","type":"article","venue":"Qualitative Theory of Dynamical Systems","topic":"Mathematical Biology Tumor Growth","field":"Mathematics","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Wilfrid Laurier University","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Hopf bifurcation; Immune system; Control theory (sociology); Mathematics; Dynamics (music); Immunotherapy; Homoclinic orbit; Stimulation; Bifurcation; Computer science; Immunology; Physics; Medicine; Internal medicine; Control (management); Nonlinear system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004705379,0.000281724,0.001797231,0.0005756282,0.00008189514,0.00000475461,0.0002817925,0.00007147356,0.00003098313],"category_scores_gemma":[0.0005673095,0.0002205614,0.0002460008,0.0009101412,0.0005791238,0.00006890071,0.0001160003,0.0001838491,5.475406e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000174731,"about_ca_system_score_gemma":0.00005793139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007590129,"about_ca_topic_score_gemma":0.000008679109,"domain_scores_codex":[0.9937619,0.003021084,0.001852856,0.000377912,0.0007631271,0.0002231194],"domain_scores_gemma":[0.9920114,0.004693483,0.00229809,0.0005671997,0.0003643926,0.00006548649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00145044,0.0004351453,0.0004734792,0.003143522,0.001440201,0.000002413524,0.01095267,0.05200136,0.02086552,0.909219,9.810482e-7,0.00001524014],"study_design_scores_gemma":[0.0007927904,0.0009988484,0.003250315,0.0005488922,0.0008632753,0.00001243935,0.02127064,0.8766347,0.0008003943,0.0946139,8.136404e-8,0.0002137638],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8503811,0.0001066245,0.1477333,0.000009114737,0.00002551942,0.0007641133,0.0005172839,0.00003144187,0.0004313958],"genre_scores_gemma":[0.9950476,6.594856e-7,0.004695145,0.000002602394,0.000002958803,0.00006544541,0.00007297943,0.00003484349,0.00007778698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8246333,"threshold_uncertainty_score":0.8994232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03676213366341705,"score_gpt":0.333297253199894,"score_spread":0.2965351195364769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}