{"id":"W4283587683","doi":"10.1136/annrheumdis-2022-eular.3422","title":"OP0229 OSTEOARTHRITIS OF THE KNEE, INFLAMMATION, AND THE EFFECT OF ADALIMUMAB (OKINADA): A RANDOMIZED PLACEBO-CONTROLLED TRIAL","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Université Laval; Alberta Bone and Joint Health Institute; University of Alberta","funders":"Sanofi Genzyme; Foundation for Research in Rheumatology; Universidad de Córdoba; Universidad de Granada; Teva Pharmaceutical Industries; Institute for Research in Biomedicine; Gilead Sciences; Universiteit Gent; Centro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológic; Amgen; Pfizer; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Adalimumab; Osteoarthritis; Internal medicine; Rheumatology; Placebo; Randomized controlled trial; Knee pain; Rheumatoid arthritis; Clinical endpoint; Synovitis; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002381772,0.002673956,0.006286121,0.0006411558,0.000759689,0.001735112,0.001180289,0.003325458,0.009548494],"category_scores_gemma":[0.002283007,0.001016938,0.003618349,0.0007014598,0.001704694,0.00146909,0.0006800743,0.003457356,0.001421888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007039248,"about_ca_system_score_gemma":0.001243284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409165,"about_ca_topic_score_gemma":0.002338519,"domain_scores_codex":[0.9988366,0.0005960876,0.00009283243,0.0002029129,0.0001044489,0.000167139],"domain_scores_gemma":[0.99889,0.0004178857,0.0002071896,0.0001011978,0.00008519881,0.0002986369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9924084,0.001603773,0.0001420195,0.000715127,0.000853278,0.00002296064,0.00001330932,0.00006473866,0.0005931232,0.00005995187,0.0002242135,0.003299001],"study_design_scores_gemma":[0.9859627,0.01244706,0.000480665,0.00003047872,0.0006161937,0.000009647963,0.000008697376,0.00009263514,0.00006861395,0.00006279226,0.0002115013,0.000009000217],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9465638,0.03330764,0.001409524,0.001500976,0.002591726,0.006852684,0.002251815,0.000252678,0.005269104],"genre_scores_gemma":[0.9716853,0.009917996,0.001717532,0.0021254,0.001802192,0.00622308,0.001471366,0.00003726429,0.005019884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009548494,"threshold_uncertainty_score":0.03194284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008061060403945948,"score_gpt":0.261458415202682,"score_spread":0.2533973547987361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}