{"id":"W4283592329","doi":"10.1186/s13063-022-06405-7","title":"Australasian Malignant PLeural Effusion (AMPLE)-3 trial: study protocol for a multi-centre randomised study comparing indwelling pleural catheter (±talc pleurodesis) versus video-assisted thoracoscopic surgery for management of malignant pleural effusion","year":2022,"lang":"en","type":"article","venue":"Trials","topic":"Pleural and Pulmonary Diseases","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"National Health and Medical Research Council; New South Wales Workers' Compensation Dust Disease Board","keywords":"Medicine; Pleurodesis; Malignant pleural effusion; Mesothelioma; Surgery; Video-assisted thoracoscopic surgery; Randomized controlled trial; Quality of life (healthcare); Cardiothoracic surgery; Adverse effect; Pleural effusion; Internal medicine; Nursing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01428475,0.004942549,0.008890348,0.0007782922,0.001380057,0.003172657,0.002508182,0.005116411,0.04566925],"category_scores_gemma":[0.01523372,0.001918339,0.005261319,0.001248377,0.002378704,0.002808989,0.001378464,0.005135941,0.007000099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003241272,"about_ca_system_score_gemma":0.005332625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002022293,"about_ca_topic_score_gemma":0.004021452,"domain_scores_codex":[0.9914972,0.005256429,0.0007784424,0.001136072,0.0005906046,0.0007411696],"domain_scores_gemma":[0.994786,0.00119666,0.001648318,0.0006618791,0.0006973218,0.001009794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9796996,0.001751823,0.0002877125,0.007015358,0.001886412,0.00006578519,0.00009046663,0.0003581372,0.0006175105,0.0006249748,0.003426584,0.004175751],"study_design_scores_gemma":[0.9844051,0.008416735,0.0006540198,0.000630194,0.0006880976,0.00002732744,0.00002514877,0.00034997,0.0001217151,0.000681027,0.003976988,0.00002367633],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.04120441,0.0035619,0.003327905,0.001669525,0.002404092,0.9349916,0.008040249,0.0003572517,0.004443109],"genre_scores_gemma":[0.03877091,0.0008368961,0.003288853,0.001113311,0.0003249471,0.951261,0.001291925,0.00003334161,0.003078735],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04566925,"threshold_uncertainty_score":0.1527789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3402614474872064,"score_gpt":0.4464202863833608,"score_spread":0.1061588388961544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}