{"id":"W4283643233","doi":"10.1039/d2cb00062h","title":"[4 + 2] and [2 + 4] cycloaddition reactions on single- and double-stranded DNA: a dual-reactive nucleoside","year":2022,"lang":"en","type":"article","venue":"RSC Chemical Biology","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Universität Zürich; Canada Foundation for Innovation; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Cycloaddition; Nucleoside; Dual (grammatical number); Chemistry; DNA; Combinatorial chemistry; Stereochemistry; Organic chemistry; Biochemistry; Philosophy; Catalysis; Linguistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005146279,0.0001529576,0.0001775521,0.00002320164,0.0002490766,0.00001510246,0.0000776336,0.000146702,0.001056059],"category_scores_gemma":[0.00004359767,0.0001604524,0.00004681723,0.0000900531,0.0001980317,0.00003008055,0.0001266794,0.0003983053,0.000007595751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009212464,"about_ca_system_score_gemma":0.00001480214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002768396,"about_ca_topic_score_gemma":0.000001871239,"domain_scores_codex":[0.9990717,0.00001333383,0.0001995124,0.000437249,0.00007059715,0.0002076499],"domain_scores_gemma":[0.9992794,0.0002834215,0.00009227984,0.0002170768,0.00001881089,0.0001089423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001910661,0.0002221202,0.0000859713,0.00001978505,0.00002851716,0.000003117607,0.00006027979,8.139652e-7,0.9955372,0.001725866,0.0005124653,0.001612851],"study_design_scores_gemma":[0.001051815,0.00003750968,0.00003753377,0.000009522396,0.00002760301,0.0001541712,0.0001935971,0.00002146115,0.9254896,0.002800731,0.06999896,0.00017751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758354,0.0000407085,0.000005003981,0.001487822,0.00002323524,0.00007021647,0.0003180359,0.00009697353,0.02212256],"genre_scores_gemma":[0.9983485,0.00002276374,0.0000572579,0.0001617059,0.0001467377,0.00019771,0.0006437561,0.00001421287,0.000407345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07004756,"threshold_uncertainty_score":0.9998571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02198460638771185,"score_gpt":0.2561844245382284,"score_spread":0.2341998181505165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}