{"id":"W4283644807","doi":"10.1007/s13346-022-01170-1","title":"Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; comparative assessment of NBM-induced liver toxicity","year":2022,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Liver physiology and pathology","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"H2020 Health; Horizon 2020 Framework Programme; H2020 Leadership in Enabling and Industrial Technologies; European Commission; Irish Research eLibrary","keywords":"Nanomedicine; Clinical trial; Drug toxicity; Medicine; Toxicity; Drug; Risk analysis (engineering); Nanotechnology; Pharmacology; Pathology; Materials science; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003812455,0.00009899337,0.000439604,0.0001965338,0.0002245721,0.000004680697,0.00009592484,0.00007669609,0.0003777917],"category_scores_gemma":[0.00009041475,0.00009057615,0.00005949703,0.0001957972,0.0003865741,0.0000624606,0.0001471288,0.0003936029,0.000002295843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000019998,"about_ca_system_score_gemma":0.0003977843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008029839,"about_ca_topic_score_gemma":0.00001882056,"domain_scores_codex":[0.9961888,0.002369715,0.0004095634,0.0003266009,0.000493144,0.0002122371],"domain_scores_gemma":[0.9967379,0.002640619,0.00006907963,0.0001595572,0.0002516638,0.0001411694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.03538128,0.001386693,0.08073651,0.0002157434,0.0002624615,0.00008574792,0.009289765,0.0001367695,0.8692372,0.00141567,0.0002366218,0.00161549],"study_design_scores_gemma":[0.001876981,0.002251416,0.9766194,0.00003201983,0.00004093381,0.00003380262,0.0003667935,0.001448113,0.01660356,0.000408351,0.0002299395,0.00008874677],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980435,0.0001881393,0.00003390153,0.0005336164,0.00005904086,0.0005842466,0.0002320881,0.000006870048,0.0003185404],"genre_scores_gemma":[0.9987698,0.0000632571,0.0008068269,0.0001050087,0.00004099762,0.00004400768,0.00004032538,0.000005801008,0.0001239968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8958828,"threshold_uncertainty_score":0.4136554,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2344747459644886,"score_gpt":0.4658731125252276,"score_spread":0.231398366560739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}