{"id":"W4283645681","doi":"10.1016/j.xcrm.2022.100693","title":"Mucosal chemokine adjuvant enhances synDNA vaccine-mediated responses to SARS-CoV-2 and provides heterologous protection in vivo","year":2022,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Food Inspection Agency; University of Manitoba; Public Health Agency of Canada","funders":"National Institute of Allergy and Infectious Diseases; Boston Biomedical; National Cancer Institute; Public Health Agency of Canada; Wistar Institute; Coalition for Epidemic Preparedness Innovations; INOVIO Pharmaceuticals; AstraZeneca","keywords":"Heterologous; Adjuvant; In vivo; Chemokine; Virology; Immunology; Medicine; Biology; Immune system; Biotechnology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001397795,0.0003683508,0.0002081386,0.0001997006,0.00008249488,0.0001911603,0.00009804095,0.0002278857,0.002221128],"category_scores_gemma":[0.0001118368,0.00007401565,0.0001420017,0.000063786,0.0001362756,0.0001653906,0.0001905025,0.0006083666,0.0003542225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001849141,"about_ca_system_score_gemma":0.0003631732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003683959,"about_ca_topic_score_gemma":0.001371941,"domain_scores_codex":[0.9998751,0.00002522851,0.000008028578,0.00001634296,0.00003144884,0.00004393205],"domain_scores_gemma":[0.9999281,0.00001009045,0.00001628907,0.000005574603,0.00001035858,0.00002948585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002649665,0.0002139036,0.0001993501,0.00005186361,0.000004024164,0.00003498857,0.0000101654,0.0001041728,0.9958588,0.00006468506,0.00007617875,0.003116831],"study_design_scores_gemma":[0.0001139186,0.006221217,0.004945276,0.00002234409,0.00002337816,0.0002268394,0.00004842954,0.001298335,0.9836504,0.00006450696,0.003378772,0.000006589398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996855,0.0006685904,0.0007644033,0.00009534678,0.00006814595,0.00004396339,0.000155862,0.00004389829,0.001304783],"genre_scores_gemma":[0.993625,0.0004752486,0.001458795,0.0000553749,0.0000289652,0.00002698335,0.0003476483,0.000009679218,0.003972154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221128,"threshold_uncertainty_score":0.007430434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03304445515988344,"score_gpt":0.3218822056865683,"score_spread":0.2888377505266848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}