{"id":"W4283656267","doi":"10.1158/2159-8290.cd-21-0576","title":"Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence","year":2022,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Astellas Pharma; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Cancer Institute; ZonMw; Movember Foundation","keywords":"Epigenomics; Prostate cancer; Circadian rhythm; Androgen; Independence (probability theory); Biology; Melatonin; Drug; Cancer; Neuroscience; Endocrinology; Pharmacology; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003256522,0.0002351141,0.000285052,0.0001801434,0.0002410578,0.0007008794,0.0002938157,0.0006226577,0.001488911],"category_scores_gemma":[0.0003379472,0.0001102721,0.0003103405,0.0001482207,0.0007025998,0.0004197417,0.0005165009,0.001708829,0.0005337434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005986143,"about_ca_system_score_gemma":0.0004192828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006204817,"about_ca_topic_score_gemma":0.002282085,"domain_scores_codex":[0.9997995,0.00003451993,0.000006926421,0.00006485456,0.00005519816,0.00003899274],"domain_scores_gemma":[0.9997817,0.00006117536,0.00004037352,0.0000201333,0.00006105616,0.00003561707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009828127,0.00005475686,0.004638693,0.0006566372,0.0001062047,0.0007006645,0.0002980529,0.001007854,0.8444254,0.007358166,0.03899601,0.1007748],"study_design_scores_gemma":[0.0001716892,0.0008790827,0.04759242,0.0002408204,0.000180792,0.002237384,0.0007374363,0.002970596,0.3829601,0.01150835,0.5503917,0.0001296314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5293621,0.2648692,0.0549351,0.1014807,0.01596289,0.0001732265,0.0058327,0.002179348,0.02520481],"genre_scores_gemma":[0.8074698,0.1147065,0.005015262,0.03724926,0.003607574,0.0001359597,0.001405809,0.0004612934,0.02994848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001488911,"threshold_uncertainty_score":0.004980922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190768478287693,"score_gpt":0.3164041521305243,"score_spread":0.2844964673476473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}