{"id":"W4283656267","doi":"10.1158/2159-8290.cd-21-0576","title":"Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence","year":2022,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Astellas Pharma; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Cancer Institute; ZonMw; Movember Foundation","keywords":"Epigenomics; Prostate cancer; Circadian rhythm; Androgen; Independence (probability theory); Biology; Melatonin; Drug; Cancer; Neuroscience; Endocrinology; Pharmacology; Hormone; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002556902,0.0002917289,0.0004304509,0.0002248639,0.0004171315,0.0001069522,0.0002059995,0.0000732854,0.0006663015],"category_scores_gemma":[0.00003238803,0.0002661604,0.0001490127,0.0007088739,0.0000950295,0.0003539992,0.0002916509,0.0004589139,0.00002848627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002636292,"about_ca_system_score_gemma":0.001757312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003481997,"about_ca_topic_score_gemma":0.000879531,"domain_scores_codex":[0.9970927,0.00009778902,0.0003548262,0.0008785363,0.0008406671,0.0007354867],"domain_scores_gemma":[0.9988239,0.00004387037,0.0001454532,0.000424696,0.0001596827,0.0004023624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01097998,0.000966116,0.577665,0.0008691496,0.00152631,0.0011758,0.02831326,0.01134756,0.1264702,0.0004316198,0.01491387,0.2253412],"study_design_scores_gemma":[0.01789794,0.003443627,0.5623298,0.001301719,0.0010309,0.0003118772,0.00857241,0.001713506,0.3101588,0.001336367,0.08913045,0.002772646],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887853,0.002504792,0.00006161844,0.00461304,0.0007469577,0.002227942,0.0004848449,0.00009828143,0.0004771793],"genre_scores_gemma":[0.9865457,0.0006932968,0.00005347599,0.0006502413,0.0004139197,0.003226333,0.0001567881,0.00006650023,0.008193689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2225685,"threshold_uncertainty_score":0.9999791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190768478287693,"score_gpt":0.3164041521305243,"score_spread":0.2844964673476473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}