{"id":"W4283656416","doi":"10.31235/osf.io/wqjsd","title":"Guerrilla eugenics: Gene drives in heritable human genome editing","year":2022,"lang":"en","type":"preprint","venue":"","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Genome editing; Eugenics; CRISPR; Genome; Biology; Genetics; Bioethics; Human genome; Cas9; Human genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.004371513,0.0004182742,0.000441882,0.0005507924,0.001080956,0.002351336,0.000907327,0.003319338,0.005007389],"category_scores_gemma":[0.01076319,0.0003456054,0.0004751323,0.0006020439,0.007082234,0.003040233,0.003820583,0.004344085,0.001726425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001174149,"about_ca_system_score_gemma":0.000936083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007797955,"about_ca_topic_score_gemma":0.0008316736,"domain_scores_codex":[0.9963626,0.001606531,0.0001075462,0.0005279435,0.001184096,0.0002112883],"domain_scores_gemma":[0.9967835,0.002027237,0.0003057537,0.0006647418,0.000112011,0.0001066858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00002622333,0.000008737712,0.0002399983,0.00008828859,0.000009608772,0.0001881246,0.0004280255,0.0007717626,0.00248359,0.9623818,0.005616934,0.02775688],"study_design_scores_gemma":[0.00002600264,0.0000541724,0.0005815091,0.0001917764,0.00002071929,0.001288764,0.0001771025,0.002853977,0.0111973,0.6563345,0.327223,0.00005126783],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"commentary","genre_scores_codex":[0.03405675,0.01165815,0.5603552,0.06396376,0.003234555,0.0001816643,0.0004010707,0.002193072,0.3239557],"genre_scores_gemma":[0.6019501,0.01173102,0.2536887,0.0210471,0.001175564,0.0005984841,0.0003598191,0.001003672,0.1084456],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.9989191,"threshold_uncertainty_score":0.02311903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00999426592768395,"score_gpt":0.3021457444646567,"score_spread":0.2921514785369728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}