{"id":"W4283661328","doi":"10.1016/j.cbi.2022.110032","title":"A gene expression biomarker identifies inhibitors of two classes of epigenome effectors in a human microarray compendium","year":2022,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada; Environmental Protection Agency; U.S. Environmental Protection Agency","keywords":"Epigenome; Biomarker; Biology; Toxicogenomics; Computational biology; Epigenetics; Effector; Panobinostat; Histone deacetylase; In silico; Histone deacetylase inhibitor; Histone; Genetics; Gene; Gene expression; DNA methylation; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004188498,0.0003234948,0.0005151616,0.0008488468,0.0002597044,0.0004943593,0.0002456115,0.00030444,0.002694737],"category_scores_gemma":[0.0006699782,0.0001930793,0.0003301531,0.0009707045,0.0001690723,0.0001636868,0.000237677,0.0003303297,0.0008165097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002648561,"about_ca_system_score_gemma":0.0005525002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003160441,"about_ca_topic_score_gemma":0.009447114,"domain_scores_codex":[0.9997043,0.00002942841,0.00002193996,0.00009711259,0.0001056599,0.00004154086],"domain_scores_gemma":[0.9995555,0.0002146399,0.00005638001,0.00005777627,0.0000864657,0.00002922313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005757074,0.0001026195,0.06273711,0.0005496814,0.0002270712,0.0003098489,0.0002278839,0.002502271,0.8360354,0.001041218,0.007896871,0.0877943],"study_design_scores_gemma":[0.00003585038,0.0005544776,0.5194181,0.00005517871,0.0005618795,0.001925895,0.0002326225,0.01047539,0.3918776,0.0008198057,0.07396537,0.00007785016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8321941,0.005554959,0.05916611,0.000940626,0.0001309748,0.0001942478,0.08435563,0.001633561,0.01582967],"genre_scores_gemma":[0.8157514,0.003186006,0.07526119,0.0008489443,0.00007817675,0.0006325838,0.08384019,0.0002526868,0.02014893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003160441,"threshold_uncertainty_score":0.009014785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02740748573993309,"score_gpt":0.3098483853163186,"score_spread":0.2824408995763855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}