{"id":"W4283662383","doi":"10.1080/2162402x.2022.2093426","title":"Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality","year":2022,"lang":"en","type":"article","venue":"OncoImmunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Cancerföreningen i Stockholm; Vetenskapsrådet; Karolinska Institutet; Cancerfonden","keywords":"Mesothelin; Chimeric antigen receptor; Cancer research; T cell; Antigen; CD28; Tumor microenvironment; Immunology; Medicine; Immune system; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00014923,0.0002614953,0.0002548093,0.0001385068,0.0001251296,0.0003605122,0.0001547916,0.0003299844,0.001259165],"category_scores_gemma":[0.0001424093,0.0001164468,0.0001646869,0.00009636027,0.0003018806,0.0002751747,0.0002264845,0.0006052981,0.00032674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105513,"about_ca_system_score_gemma":0.000286354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006740148,"about_ca_topic_score_gemma":0.00111111,"domain_scores_codex":[0.9998145,0.00004337314,0.0000150878,0.00002846591,0.00005174561,0.00004685195],"domain_scores_gemma":[0.9998862,0.00004108109,0.00003142017,0.00001379156,0.00001226964,0.00001524991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004351768,0.00001384596,0.0001528396,0.00002221284,0.000002812617,0.00003397228,0.00001209118,0.0001596796,0.9985533,0.0001537473,0.00002306314,0.0008288278],"study_design_scores_gemma":[0.000006985133,0.0001338578,0.001182735,0.000003031529,0.000005420296,0.0002379339,0.00001712841,0.001306458,0.9958587,0.00004201036,0.001203812,0.000001908453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923456,0.0009732163,0.00524379,0.0000887064,0.000008204365,0.00003511364,0.00009795895,0.0000729133,0.001134622],"genre_scores_gemma":[0.9973204,0.000303037,0.001359648,0.00003071662,0.000002464284,0.00002222094,0.00007438681,0.00001086579,0.000876182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001259165,"threshold_uncertainty_score":0.004212379,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415937153626818,"score_gpt":0.2915906756047358,"score_spread":0.2674313040684677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}