{"id":"W4283662383","doi":"10.1080/2162402x.2022.2093426","title":"Trogocytosis and fratricide killing impede MSLN-directed CAR T cell functionality","year":2022,"lang":"en","type":"article","venue":"OncoImmunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Cancerföreningen i Stockholm; Vetenskapsrådet; Karolinska Institutet; Cancerfonden","keywords":"Mesothelin; Chimeric antigen receptor; Cancer research; T cell; Antigen; CD28; Tumor microenvironment; Immunology; Medicine; Immune system; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004599093,0.0001565584,0.0003837496,0.0002308195,0.0003473543,0.00001318469,0.0001292743,0.0001116522,0.01129595],"category_scores_gemma":[0.00006548988,0.0001572971,0.0001103544,0.0004420653,0.0001515538,0.00003744291,0.0002581554,0.0007677575,0.00003530826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004043861,"about_ca_system_score_gemma":0.0002454256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007438453,"about_ca_topic_score_gemma":0.00001806512,"domain_scores_codex":[0.9982974,0.0003030965,0.0002670887,0.0003914993,0.0003319904,0.0004089081],"domain_scores_gemma":[0.9991114,0.0002275866,0.00007722565,0.0003953552,0.00009734846,0.00009113398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001707704,0.000306526,0.03249039,0.00004312805,0.0002445373,0.000122988,0.0006115878,0.00001621161,0.9381142,0.0001112797,0.001967638,0.02426385],"study_design_scores_gemma":[0.01047727,0.004380233,0.1263882,0.0000190568,0.0003271834,0.001470829,0.00409865,0.001302766,0.05190557,0.0005983719,0.7983909,0.0006409492],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835264,0.005291494,0.00004470198,0.001379203,0.0003628272,0.0003475009,0.00003228056,0.0001754957,0.008840086],"genre_scores_gemma":[0.9839249,0.0005668112,0.0003378339,0.000499346,0.00015121,0.0001207565,0.0001127859,0.00003913178,0.01424727],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8862086,"threshold_uncertainty_score":0.9896079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02415937153626818,"score_gpt":0.2915906756047358,"score_spread":0.2674313040684677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}