{"id":"W4283687598","doi":"10.1136/annrheumdis-2022-eular.1318","title":"AB0887 Designing a Phase 3b, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Investigate the Effect of Guselkumab Dosing Interval in Psoriatic Arthritis Patients with Inadequate Response to Tumor Necrosis Factor Inhibition","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"School of Medicine, New York University; Memorial University of Newfoundland; University of Glasgow; Janssen Scientific Affairs; Drexel University; Brigham and Women's Hospital; University of Rochester; Medical Center, University of Rochester; University of Pennsylvania; College of Medicine, Drexel University; University of Washington; York University","keywords":"Medicine; Psoriatic arthritis; Internal medicine; Clinical endpoint; Population; Clinical trial; Oncology; Arthritis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002215993,0.001171423,0.003039285,0.0004947548,0.0005545401,0.000747464,0.0006959763,0.001826427,0.005004183],"category_scores_gemma":[0.001605727,0.0007070717,0.001413261,0.0004298282,0.0009979297,0.0009460264,0.0003265603,0.002651561,0.0009629723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004199432,"about_ca_system_score_gemma":0.001220295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006002872,"about_ca_topic_score_gemma":0.001331747,"domain_scores_codex":[0.9990655,0.0005276851,0.00007376305,0.0001268397,0.00006457855,0.0001417735],"domain_scores_gemma":[0.9991233,0.0002792453,0.0001617808,0.00009220695,0.00008669627,0.0002568716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9553106,0.01672992,0.0007475223,0.0003925023,0.000734668,0.00004169209,0.00004702245,0.0002819504,0.007454123,0.00008726133,0.0005760256,0.01759672],"study_design_scores_gemma":[0.8910426,0.1063047,0.001337721,0.00001333298,0.0002290206,0.00001770915,0.00001154707,0.0002584163,0.0004087382,0.00005464794,0.0003123129,0.000009137205],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9899502,0.002201368,0.001017738,0.0005415151,0.0004393993,0.004118224,0.0005354179,0.0001292654,0.001066929],"genre_scores_gemma":[0.9843502,0.001341009,0.003374175,0.001766961,0.0004409956,0.006185403,0.0006282222,0.0000323512,0.00188062],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005004183,"threshold_uncertainty_score":0.01674068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02649186919727261,"score_gpt":0.2887543132606102,"score_spread":0.2622624440633377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}