{"id":"W4283690479","doi":"10.1101/2022.06.26.497644","title":"Chronic infection control relies on T cells with lower foreign antigen binding strength generated by N-nucleotide diversity","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"T-cell receptor; Terminal deoxynucleotidyl transferase; Repertoire; Biology; Chronic infection; In silico; Immunology; Pathogen; Receptor; T cell; Molecular biology; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001605069,0.0002639407,0.0003397804,0.00007851078,0.0001591184,0.0005260723,0.0002758356,0.0002976811,0.001950985],"category_scores_gemma":[0.0002448257,0.0001284808,0.0002223354,0.00006723597,0.0003258984,0.0003522637,0.0003081667,0.0004672659,0.0003516856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002557969,"about_ca_system_score_gemma":0.0003845211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006556854,"about_ca_topic_score_gemma":0.0006441695,"domain_scores_codex":[0.9999225,0.00001199302,0.000003808516,0.00001910235,0.00001761772,0.00002489041],"domain_scores_gemma":[0.9998931,0.00002530098,0.00002813104,0.00001631334,0.00001144061,0.0000257667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003083525,0.00009793493,0.006520847,0.0001654864,0.00003701297,0.000195052,0.00003999729,0.07950485,0.9003289,0.004151717,0.0003622957,0.008287457],"study_design_scores_gemma":[0.0001703959,0.0008335181,0.00913419,0.00004739488,0.00009715138,0.0003979648,0.0001092935,0.7025061,0.2747254,0.006315904,0.005624935,0.00003778811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9633355,0.0003122231,0.03341726,0.00008797775,0.00003457219,0.00001598296,0.00009317682,0.0001770129,0.002526323],"genre_scores_gemma":[0.9942731,0.0001248714,0.004781665,0.00003728801,0.000005409385,0.00001542161,0.00007401157,0.00003004812,0.0006580768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001950985,"threshold_uncertainty_score":0.006526649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007953671902955917,"score_gpt":0.1844205847398428,"score_spread":0.1764669128368869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}