{"id":"W4283690529","doi":"10.1021/acschembio.2c00387","title":"Human Diacylglycerol Kinase ε N-Terminal Segment Regulates the Phosphatidylinositol Cycle, Controlling the Rate but Not the Acyl Chain Composition of Its Lipid Intermediates","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor; Structural Genomics Consortium; University of Toronto; McMaster University; Health Sciences Centre","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Diacylglycerol kinase; Phosphatidic acid; Phosphatidylinositol; Biochemistry; Transmembrane protein; Transmembrane domain; Enzyme; Biology; Lipid bilayer; Cell biology; Enzyme activator; Biophysics; Kinase; Membrane; Chemistry; Phospholipid; Protein kinase C; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000514353,0.000183309,0.0002149697,0.00001789679,0.0003826943,0.00001585985,0.0005472099,0.0001224305,0.00004713092],"category_scores_gemma":[0.00003340596,0.0001022025,0.0001664313,0.00007589543,0.0003748045,0.000003521958,0.0002346902,0.0002779857,0.000002241312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001999421,"about_ca_system_score_gemma":0.00002469945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002575851,"about_ca_topic_score_gemma":0.000005684145,"domain_scores_codex":[0.9986538,0.0002855869,0.000368227,0.0003088891,0.0001168756,0.0002666212],"domain_scores_gemma":[0.9991862,0.0001234564,0.0002128393,0.0003767699,0.00006164057,0.00003907662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000397997,0.00007335028,0.0005163786,0.00001215192,0.0000782986,0.000002846844,0.0001876032,0.0001076276,0.9977142,0.0002710579,0.00004942121,0.0005890908],"study_design_scores_gemma":[0.000792607,0.0002564814,0.0007486938,0.000007867614,0.00006688275,0.00001900871,0.0001728572,0.0005246436,0.9941456,0.0001143784,0.003018105,0.0001328491],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996103,0.0009821741,0.0001467456,0.001995521,0.0002042616,0.000437015,0.00008734107,0.00001104168,0.00003285162],"genre_scores_gemma":[0.9961455,0.0001439692,0.000009116208,0.000926879,0.0003500988,0.0001482977,0.002205958,0.00001560036,0.00005453708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003568551,"threshold_uncertainty_score":0.4167696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007725541173671246,"score_gpt":0.2296528516275809,"score_spread":0.2219273104539097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}