{"id":"W4283690529","doi":"10.1021/acschembio.2c00387","title":"Human Diacylglycerol Kinase ε N-Terminal Segment Regulates the Phosphatidylinositol Cycle, Controlling the Rate but Not the Acyl Chain Composition of Its Lipid Intermediates","year":2022,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor; Structural Genomics Consortium; University of Toronto; McMaster University; Health Sciences Centre","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Diacylglycerol kinase; Phosphatidic acid; Phosphatidylinositol; Biochemistry; Transmembrane protein; Transmembrane domain; Enzyme; Biology; Lipid bilayer; Cell biology; Enzyme activator; Biophysics; Kinase; Membrane; Chemistry; Phospholipid; Protein kinase C; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008497165,0.0002239594,0.0001563293,0.00004956982,0.0001121404,0.0001555902,0.0001320677,0.0001602976,0.0006637609],"category_scores_gemma":[0.0001088729,0.00009423948,0.0002064502,0.00009198959,0.0001596531,0.0001295939,0.0001065436,0.0002435777,0.0004563581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702539,"about_ca_system_score_gemma":0.0001517739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005412661,"about_ca_topic_score_gemma":0.000592482,"domain_scores_codex":[0.9999443,0.000008674977,0.000004541232,0.00001882818,0.00001536708,0.000008294916],"domain_scores_gemma":[0.999954,0.000009068559,0.00001397237,0.000008025339,0.000005051396,0.000009940904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000218289,0.00001337928,0.0005743834,0.00002912019,0.000004278368,0.00004114829,0.000009358755,0.0002738004,0.9972692,0.00007941547,0.0000271364,0.001460507],"study_design_scores_gemma":[0.00002088137,0.000114548,0.006044219,0.000003560936,0.00001769747,0.0002079604,0.00001788688,0.003820802,0.9871667,0.00008545316,0.002493479,0.000006943289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949921,0.0006087202,0.00345493,0.00004200792,0.00001903457,0.00001385404,0.0002265242,0.00003240101,0.0006104546],"genre_scores_gemma":[0.9957483,0.0003697283,0.00219222,0.00002565865,0.000003690016,0.00001119409,0.0004741536,0.00001066915,0.001164365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006637609,"threshold_uncertainty_score":0.002220511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007725541173671246,"score_gpt":0.2296528516275809,"score_spread":0.2219273104539097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}