{"id":"W4283692145","doi":"10.1016/j.celrep.2022.110989","title":"Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Mount Allison University; Institut Pasteur; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Agence Nationale de la Recherche; Science Foundation Ireland; Health Research Board; Health Service Executive; Wellcome Trust; Institut National de la Santé et de la Recherche Médicale; Canadian Institute for Theoretical Astrophysics","keywords":"Immunology; Immune system; Cytokine storm; Lipopolysaccharide; TLR4; Interferon; Cytokine; Secretion; Biology; Medicine; Coronavirus disease 2019 (COVID-19); Disease; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004571738,0.000184078,0.0002016479,0.0002153065,0.0006149604,0.00003529624,0.00009508029,0.0001521331,0.007776157],"category_scores_gemma":[0.0001466923,0.0001896361,0.0001039829,0.0002284856,0.00004026223,0.0002720364,0.000114028,0.0004226502,0.0002068999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00016753,"about_ca_system_score_gemma":0.0001121806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002837513,"about_ca_topic_score_gemma":0.000002277386,"domain_scores_codex":[0.9984048,0.0003303654,0.0004805609,0.0004114331,0.00008515371,0.0002876736],"domain_scores_gemma":[0.9988673,0.000128335,0.0004399193,0.0004383427,0.0001038708,0.00002227137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005961419,0.0001873938,0.001290976,0.00001274953,0.00003638482,0.00004458922,0.0002859975,0.00008819738,0.9747958,0.00004926667,0.02100909,0.001603374],"study_design_scores_gemma":[0.00036508,0.0002920752,0.003163805,0.00001161621,0.00003088093,0.0007463167,0.0002954117,0.00001459023,0.4027966,0.00008670095,0.5920082,0.0001887172],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699291,0.0002350522,0.0004702289,0.00009095691,0.008922003,0.0002866567,0.000005071865,0.0001812131,0.01987971],"genre_scores_gemma":[0.8692335,0.00001785656,0.00004169298,0.0001628166,0.00005418713,0.00009113658,0.0005083387,0.0000234036,0.1298671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5719992,"threshold_uncertainty_score":0.9931309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009814639137322823,"score_gpt":0.2174009239178322,"score_spread":0.2075862847805094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}