{"id":"W4283692145","doi":"10.1016/j.celrep.2022.110989","title":"Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Mount Allison University; Institut Pasteur; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Agence Nationale de la Recherche; Science Foundation Ireland; Health Research Board; Health Service Executive; Wellcome Trust; Institut National de la Santé et de la Recherche Médicale; Canadian Institute for Theoretical Astrophysics","keywords":"Immunology; Immune system; Cytokine storm; Lipopolysaccharide; TLR4; Interferon; Cytokine; Secretion; Biology; Medicine; Coronavirus disease 2019 (COVID-19); Disease; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001786668,0.0002448665,0.0002431357,0.0001888252,0.0001166726,0.0004061969,0.00008816797,0.0001943474,0.001420291],"category_scores_gemma":[0.0001890192,0.0001260049,0.0001990047,0.0001381164,0.0002127121,0.0001774611,0.0002645744,0.0004645105,0.0004030101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002565797,"about_ca_system_score_gemma":0.0001489486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00029188,"about_ca_topic_score_gemma":0.0002905985,"domain_scores_codex":[0.9998227,0.00002866458,0.000011273,0.00004505771,0.00003489905,0.00005735171],"domain_scores_gemma":[0.999903,0.00001633506,0.0000276856,0.00001308621,0.00001628021,0.00002366336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003663791,0.00001089066,0.002382718,0.00001604128,0.000003522609,0.0000486054,0.00002380664,0.00006370939,0.995676,0.00004684689,0.00001918876,0.001342217],"study_design_scores_gemma":[0.00002523406,0.000456568,0.1195221,0.00001541748,0.00003071296,0.0004792937,0.0002270392,0.001724597,0.8753459,0.0004078778,0.001750341,0.00001488377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964742,0.0005038837,0.001889274,0.00003353282,0.00001365959,0.000009426255,0.0003521629,0.00003279826,0.0006910297],"genre_scores_gemma":[0.9980165,0.0002372459,0.0007730352,0.00002980673,0.000008062347,0.00001615877,0.0004072496,0.00000965953,0.0005021553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001420291,"threshold_uncertainty_score":0.004751325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009814639137322823,"score_gpt":0.2174009239178322,"score_spread":0.2075862847805094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}