{"id":"W4283692802","doi":"10.1136/annrheumdis-2022-eular.4048","title":"POS0462 HYDROXYCHLOROQUINE REDUCES THE TITERS OF ANTI-DOMAIN 1 ANTIBODIES OVER TIME IN PATIENTS WITH PERSISTENTLY POSITIVE ANTIPHOSPHOLIPID ANTIBODIES: RESULTS FROM THE APS ACTION CLINICAL DATABASE AND REPOSITORY (“REGISTRY”)","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Université Laval","funders":"Peking University; Directorate for Biological Sciences; Universidade do Estado do Rio de Janeiro; Hokkaido University; Università degli Studi di Torino; University College London; Universidad de Córdoba; Northwell Health; York University; Università degli Studi di Brescia; Peking University First Hospital; Università degli Studi di Milano; Euskal Herriko Unibertsitatea; European Commission; Johns Hopkins University; King's College London; Université Laval; Hospital for Special Surgery; Università degli Studi di Padova; Intermountain Healthcare","keywords":"Medicine; Antiphospholipid syndrome; Hydroxychloroquine; Cohort; Titer; Internal medicine; Antibody; Database; Immunology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001592133,0.0003226579,0.0008779902,0.001085608,0.0002105255,0.0008048613,0.0005707382,0.0004792417,0.003148108],"category_scores_gemma":[0.004086134,0.0002205012,0.0007815515,0.002003022,0.0001639611,0.00063032,0.0003191917,0.0004851334,0.0008523636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003237635,"about_ca_system_score_gemma":0.0006506048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001845153,"about_ca_topic_score_gemma":0.002669372,"domain_scores_codex":[0.9987973,0.0004168038,0.0002435945,0.0002240339,0.000238633,0.00007967602],"domain_scores_gemma":[0.9946412,0.001624453,0.002332118,0.0004685125,0.0006299768,0.0003036796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04458688,0.001026668,0.89413,0.0004992733,0.001247268,0.0001381171,0.00008352826,0.0002829354,0.001601264,0.00008358292,0.00494781,0.05137254],"study_design_scores_gemma":[0.005773775,0.004979437,0.9821431,0.00006992561,0.001332173,0.0005817803,0.0001030007,0.0005151359,0.001073092,0.00008528433,0.00331518,0.00002816765],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656993,0.002472218,0.0002168141,0.0002242123,0.00002742796,0.0001499975,0.0291487,0.00009960819,0.001961732],"genre_scores_gemma":[0.9591214,0.001504629,0.0007607322,0.0003197022,0.00005379474,0.0001718309,0.03703224,0.00002032311,0.001015437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003148108,"threshold_uncertainty_score":0.01053149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03466166399062531,"score_gpt":0.3196115191091856,"score_spread":0.2849498551185603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}