{"id":"W4283694644","doi":"10.1038/s41467-022-31331-2","title":"MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Environmental Health Sciences; Genentech; Associazione Italiana per la Ricerca sul Cancro; U.S. Department of Defense; European Commission; National Institutes of Health; U.S. Department of Health and Human Services; Università di Bologna; Dan L. Duncan Cancer Center, Baylor College of Medicine; National Cancer Institute; University of Rochester; National Research Council Canada; Cancer Prevention and Research Institute of Texas","keywords":"Neuroblastoma; Cancer research; Biology; Gene; Neural crest; Cell culture; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009216634,0.0001827137,0.0002084597,0.0001694022,0.0001811567,0.0003030014,0.0001063159,0.0002161084,0.0006007911],"category_scores_gemma":[0.0001063854,0.0001574735,0.0001742342,0.0001797441,0.0002108601,0.0002065731,0.0002528218,0.0003206426,0.0001400404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005804794,"about_ca_system_score_gemma":0.0002476372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001819524,"about_ca_topic_score_gemma":0.004170593,"domain_scores_codex":[0.9999096,0.000008033207,0.000006388453,0.00003086935,0.00002980298,0.00001523641],"domain_scores_gemma":[0.9999443,0.000007265045,0.00001770685,0.000005882229,0.000009342195,0.0000154443],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008735742,0.000005402445,0.001853858,0.00002316327,0.000004658052,0.00008309004,0.00001178055,0.00009547466,0.9967983,0.00006487143,0.00003176556,0.0009403199],"study_design_scores_gemma":[0.00001160711,0.0002235715,0.1056357,0.00001877394,0.00003177403,0.002459667,0.0001560453,0.002154673,0.884222,0.0003516016,0.004716533,0.0000181676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942839,0.001462176,0.00232516,0.0001029818,0.000009917036,0.00001176686,0.0008878699,0.00004179032,0.0008743386],"genre_scores_gemma":[0.9957029,0.001150602,0.001525265,0.00005307832,0.000003751015,0.00002165595,0.0007349473,0.00001522443,0.0007925706],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001819524,"threshold_uncertainty_score":0.004211664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01644324492336347,"score_gpt":0.2925697208482045,"score_spread":0.276126475924841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}