{"id":"W4283695722","doi":"10.1136/annrheumdis-2022-eular.1508","title":"POS1035 LOW RATES OF RADIOGRAPHIC PROGRESSION WITH 2 YEARS OF GUSELKUMAB, A SELECTIVE INHIBITOR OF THE INTERLEUKIN-23p19 SUBUNIT: RESULTS FROM A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF BIOLOGIC-NAÏVE PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Memorial University of Newfoundland","funders":"Sanofi Genzyme; LEO Pharma; EMD Serono; Bausch Health; Astellas Pharma; Dermira; Genentech; Coherus Biosciences; Valeant Pharmaceuticals International; Sun Pharma; Regeneron Pharmaceuticals; AbbVie; Baxalta; Gilead Sciences; Sanofi; GlaxoSmithKline; Amgen; Pfizer; Celgene; Galderma; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Psoriatic arthritis; Placebo; Internal medicine; Rheumatoid arthritis; Physical therapy; Gastroenterology; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001390676,0.0007801593,0.002469921,0.0002838295,0.0002714146,0.0008122064,0.0006819691,0.0012645,0.005436681],"category_scores_gemma":[0.001093515,0.0003654078,0.001348695,0.0003000271,0.0007286578,0.0009066011,0.0001999606,0.002357303,0.0007779522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003662651,"about_ca_system_score_gemma":0.0006712593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000682208,"about_ca_topic_score_gemma":0.001306257,"domain_scores_codex":[0.9993365,0.0003248533,0.00003992371,0.00009727631,0.00007201596,0.0001293467],"domain_scores_gemma":[0.9991682,0.0002919007,0.0001459148,0.00006654446,0.0000442353,0.0002832803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8900289,0.01078172,0.003949883,0.0006947828,0.001458854,0.0001358523,0.0000660876,0.0005321271,0.02134602,0.0001589994,0.001204706,0.0696421],"study_design_scores_gemma":[0.4986977,0.4478804,0.04573445,0.00006751659,0.001480592,0.0003566614,0.00009028137,0.001032342,0.002984781,0.0002216553,0.001404738,0.00004884236],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922494,0.004802198,0.0003274839,0.0002742469,0.0001916722,0.0002143585,0.0004109641,0.00009630773,0.001433465],"genre_scores_gemma":[0.9972881,0.000837641,0.0002186292,0.0003148917,0.00009761778,0.00008989027,0.0003249786,0.00001339636,0.0008148233],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005436681,"threshold_uncertainty_score":0.01818752,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156402776495698,"score_gpt":0.3094157466050552,"score_spread":0.2878517188400982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}