{"id":"W4283698909","doi":"10.1038/s41408-022-00695-5","title":"Gaps and opportunities in the treatment of relapsed-refractory multiple myeloma: Consensus recommendations of the NCI Multiple Myeloma Steering Committee","year":2022,"lang":"en","type":"review","venue":"Blood Cancer Journal","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saint John Regional Hospital; Dalhousie University; University of New Brunswick","funders":"National Cancer Institute; National Institutes of Health","keywords":"Multiple myeloma; Medicine; Clinical trial; Carfilzomib; Lenalidomide; Refractory (planetary science); Transplantation; Oncology; Salvage therapy; Intensive care medicine; Internal medicine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02138256,0.00105446,0.002651005,0.003429791,0.0009524965,0.003702439,0.003917171,0.00644576,0.00453578],"category_scores_gemma":[0.01786634,0.0006251566,0.002584678,0.003829936,0.001208138,0.005079403,0.002984151,0.008246696,0.003540217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00402788,"about_ca_system_score_gemma":0.02378149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006796547,"about_ca_topic_score_gemma":0.009058268,"domain_scores_codex":[0.994712,0.002146841,0.001089257,0.0003083548,0.001384134,0.000359353],"domain_scores_gemma":[0.9845257,0.004723598,0.001541175,0.0002975006,0.00751548,0.001396522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001178513,0.00009306079,0.0002278165,0.01979934,0.0001234227,0.0001932193,0.0002638592,0.0004124798,0.0004087484,0.008682512,0.4221494,0.5475282],"study_design_scores_gemma":[0.00003239074,0.00003964084,0.0001835808,0.01885407,0.0001065392,0.0001583594,0.0001359765,0.00005302199,0.00008325635,0.002696557,0.9776385,0.00001811691],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001520663,0.8588272,0.001118717,0.1224778,0.01259292,0.0002027342,0.0002379827,0.00005251426,0.004338265],"genre_scores_gemma":[0.001085995,0.9516385,0.003748189,0.03619698,0.003679815,0.000249875,0.0004155053,0.00002762975,0.002957448],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.02138256,"threshold_uncertainty_score":0.1130831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1564013048020916,"score_gpt":0.3700564653846089,"score_spread":0.2136551605825173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}