{"id":"W4283699051","doi":"10.1136/annrheumdis-2022-eular.174","title":"POS1014 IMPACT OF SERUM INTERLEUKIN 22 AS A BIOMARKER FOR THE DIFFERENTIAL USE OF MOLECULAR TARGETED DRUGS FOR PSORIATIC ARTHRITIS","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Hôpitaux Universitaires de Genève; Memorial University of Newfoundland; University of Oxford; Université de Genève; University of Glasgow; Janssen Scientific Affairs; University of Washington","keywords":"Medicine; Psoriatic arthritis; Cohort; Biomarker; Internal medicine; Immunology; Tumor necrosis factor alpha; Psoriasis; Oncology; TNF inhibitor; Disease; Etanercept","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001562099,0.0004618334,0.001037497,0.0005375873,0.0002185519,0.001427227,0.0002178549,0.000720333,0.004146214],"category_scores_gemma":[0.002447523,0.0001475944,0.0007437911,0.0004745884,0.0003009094,0.000504118,0.0002961855,0.0008644303,0.001093128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000359395,"about_ca_system_score_gemma":0.0004966162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002691926,"about_ca_topic_score_gemma":0.0005117299,"domain_scores_codex":[0.9987155,0.0005277311,0.0001285748,0.0001561276,0.0003542155,0.0001178938],"domain_scores_gemma":[0.9986241,0.000591319,0.0003394164,0.00007462191,0.0001985652,0.0001720653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.09670808,0.002399934,0.4593168,0.001093682,0.002656143,0.001452807,0.0001503566,0.001535811,0.09035219,0.0006851266,0.003024261,0.3406249],"study_design_scores_gemma":[0.001859398,0.04738567,0.885848,0.0002673114,0.0028529,0.002890262,0.000356276,0.006343277,0.03849991,0.001769738,0.01181559,0.0001116479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767243,0.01251085,0.0007530337,0.0008731829,0.0004780178,0.00008027994,0.0007170596,0.00006990751,0.007793468],"genre_scores_gemma":[0.9968597,0.00083099,0.0005132323,0.000373681,0.0001535665,0.00002621424,0.0002905513,0.000008977606,0.0009431634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004146214,"threshold_uncertainty_score":0.01387048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03190562482369493,"score_gpt":0.290817429267772,"score_spread":0.2589118044440771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}