{"id":"W4283699972","doi":"10.1016/j.celrep.2022.110990","title":"Development of allergen-specific IgE in a food-allergy model requires precisely timed B cell stimulation and is inhibited by Fgl2","year":2022,"lang":"en","type":"article","venue":"Cell Reports","topic":"Food Allergy and Anaphylaxis Research","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; National Cancer Institute; National Institutes of Health; Melvin and Bren Simon Cancer Center, Indiana University; University of California, San Francisco; University of Toronto","keywords":"Immunoglobulin E; Germinal center; Immunology; Allergy; Allergen; Antibody; Food allergy; B cell; Immunoglobulin class switching; Adjuvant; Sensitization; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004545738,0.0001719848,0.000305291,0.0002894104,0.0001370115,0.00001113193,0.00007210732,0.00008368499,0.000519446],"category_scores_gemma":[0.00002212246,0.0001748408,0.00005988336,0.0003914127,0.00005134031,0.00006775852,0.0002022278,0.0002742999,0.000002734058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001152003,"about_ca_system_score_gemma":0.000276315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001614834,"about_ca_topic_score_gemma":0.00002221964,"domain_scores_codex":[0.9977174,0.00005089258,0.0007444135,0.0004846605,0.000697917,0.0003047244],"domain_scores_gemma":[0.9991546,0.00003427741,0.0002342161,0.0003269732,0.00009526099,0.0001546337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001231915,0.002759624,0.002304747,0.000469309,0.0001895634,0.0007721313,0.01209668,0.009559761,0.8985819,0.00003550897,0.05395329,0.01804554],"study_design_scores_gemma":[0.004211407,0.001462159,0.00944033,0.0001429465,0.00000694899,0.0001143293,0.001034593,0.03068053,0.5644711,0.0004370578,0.3872783,0.0007203275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903353,0.002955965,0.0001491671,0.0001120491,0.00005469941,0.0004383324,0.000008492322,0.00002781642,0.005918143],"genre_scores_gemma":[0.9923809,0.0003050311,0.001726726,0.00006392827,0.00001438551,0.0000681499,0.0001765602,0.00003241513,0.005231884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3341109,"threshold_uncertainty_score":0.7129802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03172449595326939,"score_gpt":0.2641170949993867,"score_spread":0.2323925990461173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}