{"id":"W4283704197","doi":"10.1161/circulationaha.121.056730","title":"Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced Myocarditis","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Myocarditis; Immune system; Medicine; Immunology; CD8; Peripheral blood mononuclear cell; T cell; Immunophenotyping; Cytotoxic T cell; Biology; Antigen; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004114431,0.0001099161,0.0001795648,0.000143657,0.0003017469,0.00001035884,0.00008941209,0.00009748004,0.001032509],"category_scores_gemma":[0.00005666297,0.0001170134,0.0001106682,0.0002761064,0.00003555777,0.0001431148,0.00003893727,0.0002574933,0.0001138608],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001973765,"about_ca_system_score_gemma":0.0000501657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003971387,"about_ca_topic_score_gemma":0.000002588439,"domain_scores_codex":[0.9987808,0.0003052052,0.000460468,0.0002185831,0.00008368921,0.0001512116],"domain_scores_gemma":[0.9990464,0.00004669552,0.0005107426,0.0002431106,0.000144324,0.000008688451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009146734,0.0001692563,0.003620508,0.000007936032,0.00007925023,8.182057e-7,0.0003908158,0.0004618868,0.9939901,0.00004561777,0.0002453797,0.0008969929],"study_design_scores_gemma":[0.00114701,0.0001300993,0.3786392,0.00001252966,0.00006570319,0.00002770065,0.0005231116,0.000172209,0.6182772,0.00002301079,0.0008410062,0.0001412575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958696,0.0004392561,0.0003923207,0.00003882965,0.002253219,0.0002619921,0.00001556198,0.00006480565,0.0006643782],"genre_scores_gemma":[0.9977571,0.000006155687,0.000001851254,0.00002507146,0.00001585943,0.00005852029,0.001213131,0.00001847471,0.0009037809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3757129,"threshold_uncertainty_score":0.9998807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110144083176313,"score_gpt":0.2061392660114624,"score_spread":0.1950378251796993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}