{"id":"W4283704197","doi":"10.1161/circulationaha.121.056730","title":"Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced Myocarditis","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"U.S. National Library of Medicine; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Myocarditis; Immune system; Medicine; Immunology; CD8; Peripheral blood mononuclear cell; T cell; Immunophenotyping; Cytotoxic T cell; Biology; Antigen; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001774359,0.0003196062,0.0002076244,0.000611095,0.000206097,0.0002350623,0.0001200489,0.000250021,0.001402388],"category_scores_gemma":[0.0002342321,0.0001182152,0.0002008314,0.0001856944,0.0001716252,0.0001138494,0.0001883805,0.0002554532,0.0002604095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001136505,"about_ca_system_score_gemma":0.00005034607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122844,"about_ca_topic_score_gemma":0.0001440882,"domain_scores_codex":[0.9998742,0.00001575903,0.00001319949,0.00005332666,0.00001889643,0.00002442903],"domain_scores_gemma":[0.9998124,0.00003139952,0.00006689785,0.00002343119,0.00002512661,0.00004077919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008467473,0.0001004133,0.1441264,0.00005268566,0.00003826677,0.001289145,0.0001683123,0.0001221122,0.8468621,0.00005764389,0.0001441347,0.006191992],"study_design_scores_gemma":[0.0001193484,0.001230485,0.8646697,0.00001909152,0.0001299969,0.01326285,0.0002475831,0.001573386,0.1171602,0.0001680813,0.00140624,0.00001298894],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989631,0.0001335644,0.0004813939,0.000009972471,0.000002917292,0.00001385034,0.00008908564,0.000009932551,0.0002962967],"genre_scores_gemma":[0.9985398,0.0000663976,0.0008502485,0.00004803302,0.00001248914,0.00002277554,0.0002931207,0.000007717915,0.0001594577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001402388,"threshold_uncertainty_score":0.004691422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110144083176313,"score_gpt":0.2061392660114624,"score_spread":0.1950378251796993,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}