{"id":"W4283704737","doi":"10.1136/annrheumdis-2022-eular.1800","title":"POS0683 EFFICACY AND SAFETY OF UPADACITINIB IN TNFi-IR PATIENTS WITH RHEUMATOID ARTHRITIS FROM THREE PHASE 3 CLINICAL TRIALS","year":2022,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"","keywords":"Medicine; Rheumatoid arthritis; Clinical trial; Internal medicine; Physical therapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003021932,0.0009699437,0.002392452,0.0003539749,0.000608757,0.001544373,0.0005421971,0.0009708595,0.00367343],"category_scores_gemma":[0.001615333,0.000351667,0.003008495,0.0005730377,0.0006395536,0.0009889087,0.0003694367,0.003010571,0.0009561749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007549601,"about_ca_system_score_gemma":0.001068792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005076438,"about_ca_topic_score_gemma":0.002248446,"domain_scores_codex":[0.9992946,0.0002688442,0.00008845713,0.00009784404,0.0001029913,0.0001470766],"domain_scores_gemma":[0.9990901,0.0002800158,0.0001817202,0.00008366757,0.0001352202,0.0002293643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5401813,0.008033681,0.01531524,0.004873954,0.01210991,0.0004923979,0.0004301567,0.00603778,0.02856683,0.0008558262,0.01728945,0.3658134],"study_design_scores_gemma":[0.5628219,0.2811654,0.08007064,0.001056156,0.01606335,0.002165347,0.0003861632,0.003608685,0.01134956,0.001805114,0.03920991,0.0002977847],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9477825,0.03408477,0.001179653,0.001723018,0.000432783,0.001455771,0.003919066,0.0002423189,0.009180051],"genre_scores_gemma":[0.9788982,0.009577766,0.001361093,0.001684821,0.0001571994,0.0009835394,0.005338738,0.00003836689,0.00196039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00367343,"threshold_uncertainty_score":0.01598167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0907575257936098,"score_gpt":0.3990842654537877,"score_spread":0.3083267396601779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}