{"id":"W4283705397","doi":"10.1186/s40360-022-00581-7","title":"Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo","year":2022,"lang":"en","type":"article","venue":"BMC Pharmacology and Toxicology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Comisión Sectorial de Investigación Científica; Université Claude Bernard Lyon 1; École Normale Supérieure de Lyon; Centre National de la Recherche Scientifique; Ministère de l'Enseignement Supérieur et de la Recherche; Institut National de la Santé et de la Recherche Médicale","keywords":"Benzimidazole; Capsid; Human immunodeficiency virus (HIV); Virology; Replication (statistics); Chemistry; Viral replication; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001691064,0.0002495799,0.000472809,0.0004053271,0.0005289309,0.00001046209,0.0002266898,0.0002670427,0.00137895],"category_scores_gemma":[0.0002032482,0.000265247,0.00006017588,0.0003180915,0.0005153018,0.0001131693,0.0004462177,0.0007313163,0.0000938157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001412568,"about_ca_system_score_gemma":0.0001824539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009276467,"about_ca_topic_score_gemma":0.00005269443,"domain_scores_codex":[0.9960306,0.001704319,0.0007756574,0.0007953802,0.00007651807,0.0006175311],"domain_scores_gemma":[0.998692,0.0004970545,0.0004059459,0.0002647553,0.00007327971,0.00006699163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005181552,0.0004822147,0.02180612,0.0001027513,0.000104141,0.00002465036,0.0008149729,0.0001345071,0.9722404,0.0004177081,0.001645602,0.001708727],"study_design_scores_gemma":[0.005240199,0.0005707334,0.02271417,0.00001078631,0.00008848346,0.0001136191,0.001039519,0.0003587242,0.9630126,0.0004661388,0.00609297,0.0002920374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917676,0.005336545,0.0001486108,0.0007130019,0.000284585,0.001178902,0.000277541,0.00004432569,0.0002488942],"genre_scores_gemma":[0.9962555,0.0001202516,0.0002594355,0.0001315656,0.00003885581,0.001402172,0.0005441856,0.00002354659,0.001224469],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00922784,"threshold_uncertainty_score":0.99998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578710408395729,"score_gpt":0.2844888777547663,"score_spread":0.268701773670809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}