{"id":"W4283705397","doi":"10.1186/s40360-022-00581-7","title":"Identification of 2-(4-N,N-Dimethylaminophenyl)-5-methyl-1-phenethyl-1H-benzimidazole targeting HIV-1 CA capsid protein and inhibiting HIV-1 replication in cellulo","year":2022,"lang":"en","type":"article","venue":"BMC Pharmacology and Toxicology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Comisión Sectorial de Investigación Científica; Université Claude Bernard Lyon 1; École Normale Supérieure de Lyon; Centre National de la Recherche Scientifique; Ministère de l'Enseignement Supérieur et de la Recherche; Institut National de la Santé et de la Recherche Médicale","keywords":"Benzimidazole; Capsid; Human immunodeficiency virus (HIV); Virology; Replication (statistics); Chemistry; Viral replication; Biology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009906682,0.0003969338,0.0003402669,0.0003280744,0.0001502086,0.0003187405,0.0003044533,0.0003973557,0.0009553595],"category_scores_gemma":[0.0001086861,0.0001290578,0.0002298115,0.0002569927,0.0001084924,0.0001642406,0.0001351036,0.0003552921,0.0004714916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003098903,"about_ca_system_score_gemma":0.0002719331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001603134,"about_ca_topic_score_gemma":0.003449081,"domain_scores_codex":[0.9999295,0.000009842181,0.00000388632,0.00001085444,0.00002728409,0.00001847073],"domain_scores_gemma":[0.9999492,0.000008157559,0.00001149124,0.00000391817,0.00001362964,0.00001369056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000109146,0.00006710606,0.000197154,0.00007241812,0.000005723031,0.0001007301,0.0000119806,0.0002242559,0.9958037,0.00007965462,0.00006139286,0.003266877],"study_design_scores_gemma":[0.00007530889,0.001394255,0.00716394,0.00001958803,0.00004938807,0.0007530972,0.00003005507,0.002013344,0.9823098,0.00005740284,0.006120185,0.00001365881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777904,0.0103487,0.004848949,0.0002514347,0.00003075574,0.0001668138,0.001050199,0.0001173236,0.005395397],"genre_scores_gemma":[0.9798176,0.006092987,0.006573853,0.0001101598,0.00001776567,0.00006516853,0.001994608,0.00001936837,0.005308651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001603134,"threshold_uncertainty_score":0.003196061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578710408395729,"score_gpt":0.2844888777547663,"score_spread":0.268701773670809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}