{"id":"W4283706753","doi":"10.21203/rs.3.rs-1772205/v1","title":"Divergent Directed Evolution of a TetR-type Repressor Towards Aromatic Molecules","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Concordia University","keywords":"TetR; Repressor; Type (biology); Molecule; Chemistry; Computational biology; Biology; Biochemistry; Gene; Gene expression; Paleontology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006218739,0.0004848283,0.0005886848,0.0005396959,0.0002355143,0.0008106503,0.0006641852,0.0007517292,0.001222003],"category_scores_gemma":[0.0005541019,0.0002866895,0.0003965132,0.0005423132,0.0004704657,0.0002273408,0.0007199198,0.001664066,0.0008576482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008818638,"about_ca_system_score_gemma":0.0004771861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001659713,"about_ca_topic_score_gemma":0.001794104,"domain_scores_codex":[0.9996881,0.00006782475,0.00001872613,0.00007775886,0.00009021494,0.00005741885],"domain_scores_gemma":[0.9994493,0.0002188676,0.00006755494,0.00008504181,0.00008126929,0.0000979576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000912517,0.00002778898,0.0002989065,0.00001965386,0.000007139055,0.0001000681,0.00002908386,0.0002471633,0.9944059,0.001058186,0.00005418852,0.00366069],"study_design_scores_gemma":[0.00006520384,0.0002522057,0.01072439,0.00001989045,0.00005523501,0.001127269,0.0001514211,0.008467752,0.971692,0.0008874087,0.006516781,0.00004042957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779218,0.0004449093,0.01604588,0.0003079467,0.00008707425,0.0000403515,0.0003916431,0.0002400664,0.004520392],"genre_scores_gemma":[0.9801921,0.0003090401,0.01078369,0.0001663176,0.00002312696,0.00002355862,0.0005196013,0.0001743115,0.007808215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001659713,"threshold_uncertainty_score":0.006398439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04529121990939428,"score_gpt":0.3539649994440302,"score_spread":0.3086737795346359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}