{"id":"W4283711740","doi":"10.1161/circulationaha.122.059410","title":"Effects of Randomized Treatment With Icosapent Ethyl and a Mineral Oil Comparator on Interleukin-1β, Interleukin-6, C-Reactive Protein, Oxidized Low-Density Lipoprotein Cholesterol, Homocysteine, Lipoprotein(a), and Lipoprotein-Associated Phospholipase A2: A REDUCE-IT Biomarker Substudy","year":2022,"lang":"en","type":"article","venue":"Circulation","topic":"Fatty Acid Research and Health","field":"Nursing","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Medicine; Homocysteine; Lipoprotein; Cholesterol; Internal medicine; Interleukin; Endocrinology; Pharmacology; Cytokine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002020439,0.001521701,0.005255144,0.000636695,0.0005131928,0.001165465,0.0008156368,0.002785954,0.008800933],"category_scores_gemma":[0.004495567,0.0009932125,0.003127687,0.000459295,0.00124517,0.001334475,0.0009102256,0.002657405,0.001017887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008762998,"about_ca_system_score_gemma":0.001273515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002108449,"about_ca_topic_score_gemma":0.002811825,"domain_scores_codex":[0.9976343,0.001192453,0.0002492681,0.0003907784,0.000135691,0.0003974933],"domain_scores_gemma":[0.9973832,0.0009116701,0.0006068204,0.0002551755,0.000219403,0.0006237562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9922372,0.003501544,0.0001907079,0.0001129505,0.0003641226,0.000009335878,0.00001352817,0.00007608608,0.0005369551,0.00002698246,0.0000745746,0.002856114],"study_design_scores_gemma":[0.8133991,0.1797393,0.003316103,0.00005599539,0.001572378,0.00001691423,0.00004132442,0.0005105457,0.0005960718,0.000261685,0.000463903,0.00002680589],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904435,0.001943791,0.0004804978,0.0004297242,0.0007464436,0.003190923,0.0007841664,0.00009997014,0.001880951],"genre_scores_gemma":[0.9899254,0.000761291,0.001153332,0.0006234809,0.0003126505,0.00441229,0.000583878,0.00001542532,0.00221225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008800933,"threshold_uncertainty_score":0.02944201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749651982907513,"score_gpt":0.2759761450223558,"score_spread":0.2584796251932807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}